Increasing the share of R& D in the production of goods and services, the process of competition in different areas, which require increased competitiveness appetite, supporting knowledge and innovation resulting from research and development, in commodities and various service, and it has become an undeniable necessity. This requires identify factors influencing innovation. One of the most innovative ways to support innovation at national and international level is supporting of intellectual property rights. The aim of this paper is to examine the relationship between innovation and intellectual property rights and other factors affecting innovation in selected developed and developing countries. In this study with uses of panel data the impact of intellectual property rights, changes in GDP per capita, saving, human capital and interested rate on the innovations has been studied. The results show that intellectual property rights and demand force and saving has a direct relationship with innovation and real interest rate has an inverse relationship to innovation in both the sample countries. However, the human capital has different effects both in the country.