Aim and Background: The covid-19 pandemic and its effects on people's physical and mental health have caused an increase in worry and death anxiety in many of them. Experience has shown that people's attitude towards this disease, how to deal with it, and how much they are affected by it are different based on a number of factors and characteristics. The present study was conducted with the aim of investigating the prediction of death anxiety based on personality characteristics and self-concept in patients with covid-19. Methods and Materials: This research is correlational. The research population consisted of all the patients with covid-19 who visited Masih Deneshvari, Lavasani and Firozabadi hospitals from March 1400 to May 1401, and 205 of them were selected as available sampling based on Morgan's table that participated in the research online. The required information was collected through Templer's death anxiety scale (1970), the short form of Neo's five-factor personality questionnaire (1985) and Lawrence's (1997) self-concept. To analyze the data, Pearson's correlation test and multivariate regression analysis were used using SPSS version 26 software. Findings: The findings of the research showed that there is a relationship between personality traits (-0. 64) and God concept (-0. 59) with death-anxiety (p<0. 05). Also, the results showed that there is a positive and meaningful relationship with death anxiety in the components of personality traits, and extroversion, flexibility, agreeableness, and responsibility, as well as in the components of God concept,Influence, acceptance, challenge and benevolence, there is an inverse and meaningful relationship. Conclusions: It seems that the personality traits as a variable can be effective in reducing the death anxiety of corona patients, also the use of positive God concept against mental pressure makes him adapt better to the conditions and can It will be useful to spend the length of its treatment.