NAFTA and ASEAN were concluded to pursue certain goals. ASEAN, being developed as for political reasons, gradually expanded its work scope into economic, trade, security, and cultural extents. NAFTA on the other hand has been able to form an integrated economic and trade system. According to documents regarding the observation of human rights within ASEAN and NAFTA frames, it is clearly indicated that they have persistently considered the issues related to such issues. The present paper tries to analyze ASEAN and NAFTA degree of commitment to the improvement of human rights in the region, and to compare these two regional agreements efficiency on the above mentioned issue. Therefore, the performance of each agreement is studied separately in order to determine its strengths and weaknesses. The results of the study show that ASEAN, due to its region-specific complexity and particular difficulties, has underperformed NAFTA concerning its commitment to the observation of human rights.