The role of regional actors in the process of state-building in Afghanistan during the Taliban era and after his fall can be in terms of influencing the three key players, including Iran, Pakistan and Russia and actors on the periphery of Europe, Japan and semi-peripheral players include America, Saudi Arabia, India and China split. Political, geographical, economic, social and ethnic Afghanistan has made this country has always been under the influence of regional and trans-regional powers. Pakistan is one of the most influential countries in developments in Afghanistan so that in the period of Taliban rule, the relations between the two countries was very good but after the fall of the Taliban, relations between the two countries were severely strained. During the five years of Taliban rule led to many difficulties for the Government of India and in fact, unprecedented expansion of terrorist infiltration and destabilization in Kashmir Valley yielded but relations between the two countries improved after the fall of the Taliban. Eradication of the Taliban regime fall under major threat from Iran's eastern borders and groups close to Iran gained the power in Afghanistan and promotes ties with Iran.This paper explores and analyzes the role of regional and sub-regional actors in the three countries, Pakistan, India and Iran and their influence in the process of state-building in Afghanistan during after the fall of the Taliban. Significant topic in this article, so as to Iran and Pakistan have already cast their Afghan crisis the semi-peripheral status have found that Pakistan's role was overshadowed by the role of America. Iran also has the potential to influence Afghanistan but seriously hinder America from using this feature.