Introduction: In this study, the role of resilience, locus of control, and social health in predicting post-traumatic growth in cancer patients was investigated. Materials and Methods: In this correlation-regression study in Mashhad-Iran, 212 patients (143 women and 69 men) with diagnosed cancer were selected using the convenient sampling method. Post-traumatic growth, resilience, locus of control, and social health questionnaires were used online. Data were analyzed using Pearson correlation and multiple regression methods in SPSS version 26 software. Results: The results showed that there is a significant relationship between resilience, locus of control, and social health with post-traumatic growth (P< 0. 05). Also the results showed that resilience and social health are predictors of post-traumatic growth (P< 0. 05). However, the locus of control cannot predict post-traumatic growth in cancer patients (P> 0. 05). Conclusion: Based on the findings, if resilience and social health are more, it can predict post-traumatic growth in cancer patients.