Allameh Tabatabayi, relying on the rational and revelatory foundations of Shiite Islamic culture, confronted the opinions and discourses of his era, including liberalism, theoretically and practically. This research, with a descriptive and analytical method, aims to analyze and present his theoretical and practical encounter with liberalism by referring to his written sources, documents and works. In this confrontation he uses: a) ontological principles of realism, gradationality of existence and causality, b) epistemological principles of effectiveness of the tools of knowledge, including sense, reason, and revelation, and c) anthropological principles of two-dimensionality of human being, human nature by a precise and systematic presentation. Allameh`s practical encounter includes forming intellectual and scientific circles such as: the circle of interpretation of the Holy Quran and. ., spreading the teachings of Quran, Sunnah and Wisdom.