Introduction: Safety culture is a term, which is used repeatedly in the assessment of safety status of companies. The aim of the present study was to investigate the parameters and factors influencing organizational safety culture in the Iranian thermal power plants industry.Methods: The triangulation approach was used for data generation in this grounded theory study. Nineteen participants from a variety of work groups at three thermal power plants of Iran (Shazand, Shahid rajaei Ghazvin, and ramin Ahwaz) took part in focus group interviews, individual interviews, field observations, and focus group discussions.Thematic analysis was conducted to emerge and identify contributing factors.Results: The thematic analysis identified 9 sets of parameters for achieving safety culture as follows: (1) training, briefing and competency, (2) vision, leadership and commitment, (3) laws, rules and work procedures, (4) safety and crisis management, (5) individual agents, (6) Management style and organizational communication, (7) participation and commitment of personnel, supervisors and middle managements, (8) non-organizational agents, and (9) to make available foundations and source managements.Conclusions: The results indicated that an improvement in each parameter is necessary to achieve top safety culture. Moreover, proportionate to the conditions of each company, measures should be taken for the imporovement of actions of safety status and to accomplish pre-determined targets.