Background and Objective: Repetitive movements and overexertion during occupational activities can lead to musculoskeletal disorders in the upper limbs. Regarding this, the aim of the present study was to assess the ergonomic risk factors of the upper limb extremities using modified Revised Strain Index (RSI) and threshold limit value for hand activity level (TLV-HAL) methods in hand-swen shoe workers in Tabriz, Iran.Materials and Methods: This cross-sectional sudy was conducted on 218 hand-swen shoe workers to assess their stergonomic exposure using the RSI and TLV-HAL methods. The assesment of the study variables was acomplished through direct observation and videotaping of the work-cycles. The data were analyzed by descriptive and analytical methods, such as one-way ANOVA, Spearman correlation, and Kappa statistics.Results: In this study, 218 workers were recruited working in three tasks of preparation (n=69), sewing (n=63), and shoemaking (n=86). The mean scores of RSI for sewing, preparation, and shoemaking workers were 9.30, 46.10, and 95.90, respectively. Furthemore, the mean scores of TLV-HAL for these tasks were 0.27, 0.81, and 1.70, respectively. Almost all workers in preparation and shoemaking tasks were categorized in the group with hazardous level of exposure, while the sewing workers were classified in the group of safe exposure level. The TLV-HAL scores were significantly correlated with the RSI scores.Conclusion: According to the results, the workers in preparation and shoemaking tasks were at a higher risk of upper limbs musculoskeletal disorders due to repetitive actions and overexertion. Therefore, ergonomic interventions are suggested for these tasks to reduce the level of these risk factors.