There are cultural issues in the era of Imam Reza (A.S.) that create review of Islamic culture especially Shia Muslim culture. In this context, he took advantages by Enlightenment and using available fields and could solve these problems by doing extensive cultural activities and manage cultural system of the Shia community. The aim of this article is to answer this question that what cultural problems exist in the era of imam reza According to the cultural policy- making approach and what actions did Imam Reza (A.S.) to solve them? By searching, collection and processing the information with descriptive analytical method, findings show that cultural problems during immate of imam reza include like “shiite leadership peril”, “Ideological deviations in translation movement”, “the emergence of various religions and sects”, “the Rscientific-religious ignorance in the society”, “Rumors and lies against Ahlul Bayt (A.S.) ”, ”falsification and forghing the hadiths” “government deception" He responded to these problems by a series of political actions (that his cultural policy making have shaped) such as “explicit declaration of Shiite leadership”, “training elite students”, “scientific - religious meetings”, “scientific debates”, missionary trips”, “restoration of the prophetic hadiths”, “explaining the true traditions and cursing counterfeiters”, “cursing and excommunicating Some sects”, “developing all aspects of the spread of science”, “spread Shia”, “neutralizing the deceitful plots of government”.