According to some interpreters and Koranic researchers’ views, sign 3 in Surah Maedeh is not in semantic harmony with the preceding and following signs. Such disharmony is mostly due to the kind of attitude towards the Koranic texts in which the texts has been taken into consideration according to the common rules of tradition as well as the syntagmatic and paradigmatic relations. However, by changing that attitude as well as skipping the syntagmatic order, the sign can be defined within a particular mechanism, emphasizing there: the situation of descending Maedeh and its relevance to the preceding Surah which specially expresses such significant issues as prophets’ invitation, lack of difference among them, people of the Book’s beliefs and reactions especially Jewish ones, a list of lawful and unlawful decrees, people’s covenant especiallythat of Bani Israel as well as hypocrites secret activities in the Islamic communities. Moreover, some indications such as convergent words, parallel structures as well as repetition patterns in the Surah denote the important issue “guardianship”, the issue according to the Shiite’s narrations, based on which the religion was completed with and as a result of which unbeliever became hopeless, those unbelievers who were of the people of the Book and the hypocrites’collaborators. They broke their promise and deviated the divine decrees, being of the Prophet Muhammad’s enemies. Signs 55, 56, and 67 of the Surah denote their enmity especially after the formal announcement of Imam Ali’s guardianship on Ghadeer Day. Their hopelessness was due to the fact that Islam would prevent their promise-breaking with the power of guardianship.