"Tazkieh" is one of the significant indices of Islamic culture that its semantic field explanation requires a lexical and Quranic analysis. To do so, in addition to dictionaries, the applications of "Zakv" have been semantically studied in Holy Quran; having special structure and discovering the linguistic relations of the synonyms and antonyms, multidimensional looks have been induced leading to precise meanings. The term "Tazkieh" is not mentioned in Quran; however, its derivatives have been used 59 times, all presenting a central meaning that is the unjustifiable disqualification and its eviction from salubrious essence. The other items such as growth, adjustment, sanctification, blessing, and merit are of its effects and equipment. Bearing these in mind, Zakat in Quranic culture is one of the Tazkieh foundations; consequently, the objective of the present paper, considering this central meaning, is the analysis of all "Zakv" applications particularly zakat, exploring their relationship with Tazkieh, and their role in Quranic construction of Tazkieh. Moreover, the factors, results, and obstacles of Tazkieh from Quran viewpoint are explained.