In many environments, rocks are usually exposed to continuous wetting and drying cycles. The number of wetting-drying cycles will exacerbate weathering and reduce the mechanical quality of the rock which results in geological disasters. The effects of alternating wetting and drying cycles on rocks degradation have a greater impact than long-time soaking, which is a critical issue in the sustainability of rock mass engineering. In this research, sandstone specimens of Lalun Formation in Lushan area were investigated and the effect of wetting-drying cycles (0, 1, 4, 16) was examined on the physical properties including effective porosity, P-wave velocity, dry and saturated specific weight, mechanical properties including indirect tensile strength, uniaxial compressive strength, elasticity modulus, triaxial compressive strength, cohesion, and internal friction angle. The results indicate that by increasing the wetting-drying cycles, the effective porosity increased while the dry and saturated specific weight, P-wave velocity, tensile strength, uniaxial compressive strength, triaxial compressive strength, elasticity modulus, cohesion, and internal friction angle decreased.