Background and Purpose: Many researchers investigated the role of commercialization of knowledge and entrepreneurship discussion, but researchers have not paid much attention to the importance of the relationship between the knowledge and skills acquired with earning money and its role in academic dynamism and enthusiasm. Also, it seems that fewer researchers have investigated the role of commercialization of knowledge on children. Thus, the purpose of this research was to study the role of the practicality of knowledge and its commercialization in academic dynamics and the mental health of students. Method: This article was done using the descriptive method and library study so that different information about the research topic from different information sources including articles, university books, and domestic and foreign scientific sources from reliable scientific search databases such as Magiran, Elsevier, PubMed, and Google Scholar search engines were collected and described, explained and discussed. Search with keywords such as commercialization of knowledge, application of knowledge, benefits, and advantages of commercialization of knowledge, commercialization of knowledge, and mental health from 2004 to 2023 were collected described, explained, and discussed. Results: The commercialization of knowledge has many benefits and challenges for children and their families around the world. Commercialization is like a double-edged sword that in some ways can cause the growth and improvement of children's lives and well-being, and on the other hand, it may harm their well-being. Conclusion: In this research, while dealing with the concept of commercialization, the necessity, benefits, and challenges of commercialization of knowledge on children's well-being, lack of employment of graduates and its relationship with mental health, vocational training, and job skills in children and adolescents have been discussed and investigated.