Background and Purpose: Chronic pain at an early age can lead to serious psychological, social, and academic issues and negatively impact cognitive functioning. Due to the limitations of medical treatments, psychological interventions can offer effective solutions to improve quality of life and reduce pain. This review study aimed to determine the effectiveness of psychological interventions in treating children and adolescents with chronic pain. Method: Through a systematic review study, all selected articles were evaluated by the research authors using specialized keywords in external databases such as Google Scholar, PubMed, ProQuest, EMBASE, PsycINFO, and Scopus, covering the period from January 2001 to July 2024. A total of 973 published English articles were reviewed, considering inclusion criteria and quality assessment using the PRISMA model. Based on the final qualitative evaluation, 38 articles were selected and examined to address the research questions. Results: The results of the studies indicate the effectiveness of biofeedback-relaxation (7 studies), mindfulness-based interventions (9 studies), acceptance and commitment therapy (8 studies), cognitive-behavioral therapy (10 studies), and compassion-focused therapy (3 studies) on the psychological and physical health of children and adolescents with chronic pain. Conclusion: Psychological interventions have proven to be significantly effective for children and adolescents with chronic pain. These therapies have reduced pain intensity, stress, anxiety, depression, and pain-related disabilities. Conversely, they have improved quality of life, coping skills, physical functioning, and life satisfaction in patients. Overall, these treatments have not only alleviated negative symptoms but also enhanced various aspects of the patients' lives.