Background: This study aimed to identify COVID-19 mortality risk factors and relevant laboratory markers to inform preventionand treatment strategies.Methods: This cross-sectional study was conducted in Iran, involving 1561 patients diagnosed with COVID-19 between 2019 and2021. Demographic, clinical, and laboratory data were collected from hospital records and analyzed using a logistic regressionmodel.Results: The mortality rate attributed to COVID-19 in this study was 24.7%. Identified risk factors for mortality included intubation,multiple chronic conditions, liver or kidney disease or cancer, low RBC levels, and abnormal creatinine (Cr) levels. The adjustedodds ratios (adjOR) and 95% confidence intervals (CIs) for these factors were as follows: intubation (70.75, 14.07:355.84),concurrent chronic diseases (24.29, 3.25:181.24), liver or kidney disease or cancer (5.13, 1.21:21.81), low RBC levels (5.21,1.24:21.79), and abnormal Cr levels (5.09, 1.21:21.43).Conclusion: The findings from this study indicated that several factors, including intubation, multiple chronic conditions, liver orkidney disease or cancer, and low Cr levels were associated with a higher risk of death from COVID-19. These results highlight thesignificance of continuous monitoring and specialized care for patients exhibiting these risk factors to reduce the risk of COVID-19mortality