In this study, the effects of important ground motion parameters and site conditions on linear and nonlinear, pseudo-acceleration and input energy response spectra are evaluated. These parameters include magnitude, epicentral distance of recording station, strong motion duration, soil conditions, damping and ductility. A total of 620 Iran’s earthquake timehistories (1240 horizontal and 619 vertical components) recorded by ISMN (Iranian Strong Motion Network) were selected for this study. The accelerographs are classified based on parameters of earthquake ground motion and site conditions. Statistical investigations are made on the response spectra of the accelerographs of these groups and it is shown that these parameters significantly affect the shape and magnitude of pseudo acceleration and input energy response spectra. Finally, based on these studies, some pseudo acceleration and yield acceleration design spectra are proposed for the region of Iran.