Phosphogypsum is a by-product of phosphate fertilizer plants and chemical industries. As it is contaminated with the impurities that impair the strength development of calcined products, it can be used as partial replacement of cement. The present paper deals with the experimental investigation on compressive, tensile and flexural strength characteristics of partially cement replaced phosphogypsum concrete using 0%.,10%, 20%, 30% and 40% replacement with different water-binder ratios of 0040, 0.45, 0.50, 0.55, 0.60 and 0.65. The strength characteristics are studied by casting and testing a total of 450 specimens, which consists of 270 cubes, 90 cylinders and 90 beams for 7,28 and 90 days. It is shown that a part of Portland cement can be replaced with phosphogypsum to develop a good and hardened concrete to achieve economy; above 10% replacement of phosphogypsum in concrete lead to drastic reduction not only in the compressive strength but in the split-tensile strength also; the flexural strength decreases as width and number of cracks increases significantly at replacement above 10% of cement with phosphogypsum at different water binder ratios.