To achieve a suitable anesthetic drug for rapid anesthesia with long-term and safe recovery, we investigate the anesthetic effect of lavender essential oil on Sistan Hake (Schizothorax) and drugs MS-222, clove essential oil and 2-phenoxyethanol on common carp. 260 Schizothorax fry with average weight and total length of 58. 69 ± 1. 50 g and 20. 77 ± 1. 16 cm, respectively, were anesthetized by bath method at concentrations of 200, 300 and 400 ppm lavender essential oil. Fish samples were taken at two times, zero (10 minutes after anesthesia) and 24 hours after anesthesia to examine AST, ALT and ALP enzymes and histological tests. In studying the effect of three anesthetic drugs MS-222, clove essential oil and 2-phenoxyethanol, first the effective and lethal concentrations of each drug were determined. Then, the carp were blood sampled at 0, 1, 12, 24 and 72 hours after anesthesia and the hematological parameters including hematocrit, hemoglobin level, red blood cell count MCV, MCH, MCHC and total and differential white blood cell count were compared among the treatments. The activity levels of serum enzymes including ALP, AST, ALT and LDH were also measured and compared. The results showed that these drugs did not have a significant effect on serum enzymes.