Background and Aim: Apart from the physical effects that COVID-19 causes, the disease is also associated with various psychological problems that required research and clinical attention. Purpose of this study was to compare the effectiveness of in-person and telehealth Cognitive-Behavioral Therapy (CBT) in people who have recovered from COVID-19. Materials and Methods: The present study was a quasi-experimental study with a pre-post design, a control group, and three-month follow-up. The statistical population consisted of patients who recovered from COVID-19 in Tehran between 2022-2023, of which 45 patients were selected using a convenience sampling method and randomly divided into three groups including the two study groups: in-person CBT and telehealth CBT group (15 patients for each) and a control group (15 patients). The in-person CBT group received 11 sessions, and the telehealth CBT group received 12 sessions. Research instruments included the Depression, Anxiety, and Stress Scale (DASS-21) and the Resilience Scale (RS). The data were analyzed using repeated measures analysis of variance. Results: The results showed that although both treatments led to improvements in psychological distress (P<0. 01) and resilience (P< 0. 01), the effectiveness of in-person CBT was greater and statistically significant. Between effects size for depression, anxiety, stress and resilience was 0. 37, 0. 38, 0. 44, and 0. 64, respectively. Conclusion: The study results show that both in-person and virtual CBT lead to improvements in psychological distress and resilience in patients with a COVID-19 background compared to the control group, and the improvement rate for in-person CBT is higher in compared to the virtual group. In fact, in-person CBT leads to significant improvements in psychological distress and resilience