1. Introduction: Two phase gas-liquid flows occur in a wide variety of situations, i. e., in water supply systems, petroleum industry, pressurized tunnels and pipelines, culverts and water conduits (Mishima and Hibiki, 1996, Kabiri-Samani and Borghei, 2010). Air entrainment into a pipeline is a result of vortices at water intakes. Due to the severity of two-phase air-water flow at hydraulic systems, estimation of the dynamic pressure and pressure fluctuations in such systems is of great importance in practice (Yan et al., 2014). Most of the former studies have focused on two-phase gas-liquid flow in micro-channels and small pipelines, however, there is a lack of fundamental studies on pipelines with larger dimensions as used in hydraulic systems. Recently, some computational intelligence approaches such as ANN and ANFIS are very effectively used to predict complex problems with several parameters involved (Jang et al., 1997, Sebakhi, 2010, Fan and Yan, 2014). The present study focuses on estimation of dynamic pressure in two-phase air-water flow using ANN and ANFIS combined with PSO algorithm and subtractive clustering technique...