Introduction: Primary care organizations are entities through which clinical governance is developed at a confined level. To implement clinical governance in primary care, awareness of principles, prerequisites and barriers of this quality improvement paradigm is necessary. The aim of this study is to gather evidence of implementing clinical governance in primary care organizations.Data sources: The primary search was conducted in July 2012. PubMed, Web of Science, Emerald, Springer link, and MD Consult were searched using the following MESH keywords, “clinical governance” and “primary care”Study selection: The search was limited to English language journals with no time limitation. Articles that were either quantitative or qualitative on the concepts of implementing clinical governance in primary care were eligible for this study. From the selected articles, data on principles, prerequisites and barriers of clinical governance in primary health care were extracted and classified in the extraction tables.Results: We categorized our findings about the principles of clinical governance in primary care in four groups, general principles, principles related to staff, patient and communication. Prerequisites were classified in eight clusters, same as the seven dimensions of the National Health System (NHS) models of clinical governance. Barriers were sorted out in five categories, structure, organizing, cultural, resource, theoretical and logistical.Conclusion: Primary care organizations must provide budget holdings, incentivized programs, data feedback, peer reviews, education, human relations, health information technology (HIT) support, and resources. Key elements include, enrolled populations, interdisciplinary team approach, HIT interoperability and access between all providers and patients, devolution of hospital based services into the community, inter-sectorial integration, blended payments, and a balance of clinical, corporate, and communal governance.