Introduction: This study was conducted in Yazd province to investigate the relation between socio-economic factors and CAD.Materials and Methods: This retrospective case-control study based on hospital was performed from January 2011 to October 2012 in Yazd province. The total sample size achieved from the statistical software was 500 patients (n=250 in case and n=250 in control group). The data were collected using a questionnaire (face to face interviews), laboratory and anthropometric measurements and physical examination. To analyze the results, statistical tests such as chi-square, student T-test and Conditional Multiple Logistic Regression were conducted.Result: Elementary education and total family monthly income <500 thousand Tomans were considerably higher in the case group than the control group. Moreover, the frequency of families with rural insurance and with >6 member in the case group was statistically and significantly higher. After checking the simultaneous effect of socio–economic variables in the logistic regression model, elementary education still showed a significant relation (OR=10.462, 95%CI: 1.68-65.33). Also the findings indicate that families with 700,000-1,000,000 Tomans of monthly income were in lower risk of getting CAD (OR=0.275, 95%CI: 0.078- 0.97). In addition, the risk of getting CAD in city residents was 9.3 (95%CI: 1.220-71.041) times higher than that of rural residents.Conclusions: Overall, it seems that urbanization, poor education and low income can play a role in the causation of CAD in Yazd province. So for the prevention of CAD, promoting healthy lifestyles, alleviating poverty, increasing knowledge about CAD risk factors and national policy changes seem to be necessary.