سال:1397 | دوره: | شماره: |تعداد مقالات:6

Systemic Lupus Erythematosus (SLE) is a chronic human autoimmune disease, which is characterized by increased activity of B cells and production of antibodies against tissue antigens. It engages many tissues and organs, including joints, kidneys, heart, and the nervous system. Although the exact pathogenesis of SLE remains to be elucidated, it is suggested that genetic background plays a paramount role in SLE etiology. Increasing evidence is indicating an important role for interleukins in progression of SLE. Interleukins are a group of cytokines secreted by T helper cells, monocytes, macrophages, and B cells, which are involved in growth and differentiation of T and B cells. The expression level of interleukins is influenced greatly by genetic composition. Therefore, somepolymorphismscan control the expression of interleukins. Consequently, genetic studies can shed lightonour understanding of SLE nature. Therefore, in the present study, the researchers reviewed the roles of eight key interleukin polymorphisms and their effects on SLE pathogenic.

Dear Editor, Vitamin D (25(OH)D) deficiency is a worldwide health problem. It can increase the risk of many diseases, notably cancers (1-3). More than two billion people have vitamin D deficiency (25(OH)D < 50 nmol/L) around the world (4). Vitamin D is classified in the secosteroids hormone, which is hydroxylated in the liver to form 25-hydroxy vitamin D (25(OH)D). After further hydroxylation, the biologically active metabolite, 1, 25(OH)2D, was present in the kidneys (5). ...

Dear Editor, Hepatocellular carcinoma (HCC) is a common primary liver malignancy worldwide with a poor prognosis (1) and is the third leading cause of cancer-related deaths (2). Chronic hepatitis B (HBV) infection, which can cause liver inflammation, has been seen in many individuals with HCC. In addition, fibrosis and cirrhosis are inevitable complications of the infection, which leads to the death of a patient (3, 4)...

Background: MicroRNAs (miRNAs) play significant roles in several physiological procedures such as embryo implantation. Recently, findings have indicated that aberrant miRNAs gene expression and single nucleotide polymorphism in the gene encoded miRNAs may be contributed to the pathogenesis of recurrent pregnancy loss (RPL). This investigation aimed to examine potential associations between the two precursor miRNA SNPs miR-196a2 T > C and miR-499 A > G and susceptibility to RPL. Methods: We were analyzing a total of 200 subjects, which consisted of 100 women who experienced three or more recurrent miscarriages and 100 healthy women with one child and without historical aberrations. The genotypic frequencies of two SNPs were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique to assess the association between the presence miRNA gene variant with the risk of RPL. Results: The genotypes frequency of miR-499 gene polymorphism AA/AG + GG and GG/AG + AA showed a statistically significant association with the risk of RPL (P = 0. 019; OR= 2. 003; 95% CI, 1. 116-3. 594) and (P = 0. 024; OR= 2. 100; 95% CI, 1. 095-4. 025), respectively. The genotypes frequency of miR-196a2 gene polymorphisms did not reveal a statistically significant difference across the two groups (P > 0. 05). Conclusions: Our findings proposed that nucleotide changes in miR-499 gene encoding region may be contributed as a genetic predisposition factor to RPL, whereas the miR-196a2 gene variation cannot be a negative effect on pregnancy outcome.

Dear Editor, During the last decade some studies have focused on the important role of phenolic compounds from dietary plants in prevention and management of neurodegenerative disorders such as Alzheimer’ s disease (AD) and Parkinson’ s disease (PD)....

Background: The overgrowing resistance of the species of candida toward anti-fungus drugs has necessitated the use of compounds with antifungal features. Some plants have antimicrobial features due to their polyphenols components. This paper aims at exploring the anti-fungus effects of Zataria multiflora against Candida albicans. Methods: A total of 20 g of the dried and pounded leaves of the Zataria multiflora was used and its extract was prepared in the rotary device. Various concentrations of all extracts were prepared in the 96 cell microplate. MIC and diameter of the inhibitory shield were measured by dilution method and agar disk, respectively. Results: The Zataria multiflora extract showed good antifungal effects against Candida albicans sample. Therefore, this plant extract can replace chemical drugs and be used against candida-caused infection upon completion of this research trend. Conclusions: In the present study the principles of the extract, different methods of minimuminhibitory concentration (MIC), and mode of action of the extract are discussed.