Background: The aim of this study was to investigate the effects of knowledge, attitude and practice of the households on the prevention and control Cutaneous Leishmaniasis.Methods: This study was a cross-sectional, analytical. The population consisted of the residents in the south of Shiraz. The sample size was 300 and they were selected randomly. For analyzed using the descriptive indices as well as in-depended T-test, chisquare test and ANOVA. The SPSS software 16 was used for analysis.Results: The mean age of the participants was 36.1±13.6. The mean and standard deviation scores of knowledge, attitude and practice were 16.85±3.5, 34.38±6.43 and 5.6±1.9, respectively. Pearson correlation coefficient showed that the mean awareness (r= 0.13, P-value=0.02) was more correlated with the mean practice compared to the mean attitude (r=0.17, P-value=0.00). However, both variables of knowledge and attitude had a significant relationship with practice (p-value=0.00).Conclusion: Generally, the results of our study showed that the scores of knowledge and practice were lower than the mean score, and the attitude score was better than the two other scores.