Background: Vacillation between conventional healthcare professionals and traditional bone setters (TBS) for musculoskeletal (MSK) disorders is still common despite shortcomings and complications associated with TBS services. Objectives: This study assessed knowledge and attitude about the practice of TBS and its use for MSK disorders among Nigerian rural dwellers. Methods: This cross-sectional study utilized a multistage sampling method based on theWorld Health Organization procedures for a community-based survey to recruit 398 (213 males and 185 females) respondents from two randomly selected rural communities. A validated questionnaire adapted from relevant previous studies was used as a tool in this study. A household was served as the Primary Sampling Unit (PSU) and 60 PSUs were randomly selected. Results: The lifetime and 12-month prevalence of MSK disorders were 27. 6% and 25. 6%, respectively. Based on 12-month prevalence, neck (16, 21. 6%) and shoulder (12, 17. 6%) were the most affected body parts. The lifetime (i. e. “ ever use” ) and point (“ current use” ) prevalence of treatment by TBS were 19. 3% and 3. 8%, respectively. Among those who had ever experienced MSK disorders, 13. 3% had experienced only treatment by TBS services, whereas 6. 0% had used both treatment by TBS and orthodox medicine. Common services received by TBS were massage (61. 0%), splinting (14. 3%), traction (11. 7%), and scarification (10. 4%). Cost-effectiveness (42. 9%), distance/accessibility (35. 1%), and cultural beliefs (15. 9%) were the major reasons for TBS patronage. Using TBS services was not significantly associated with socio-demographic variables (P > 0. 05). Also, 57. 3% of the respondents acknowledged that TBS services were associated with complications, such as gangrene (19. 7%), malunion/nonunion of fractures (36. 0%), paralysis (19. 3%), joint instability (7. 5%), and chronic osteomyelitis (6. 6%). Users of the TBS services believed that they were effective in maintaining a healthy life (40. 7%), with fewer side effects (30. 0%), more effective (11. 7%), and healthier than orthodox medicine (23. 1%). Conclusions: There was a positive attitude towards treatment by TBS for MSK disorders, despite the complications and shortcomings that arise from the practice. Cost-effectiveness, socio-cultural beliefs, and easy access have increased patronage of treatment by TBS regardless of the socio-demographic characteristics of the people.