Today, the aquaculture industry has a special status as one of the most important economic sub-sectors in providing food security, trade, job creation and depriving rural areas of the world. This study was aimed to determine the factors affecting sustainable aquaculture in Lorestan province. This applied research is conducted in a survey method and its descriptive-correlative research type. The statistical population consisted of all fishery farms in Lorestan province. The sample size was determined by using Cochran formula. In this study, the sustainability of aquaculture farms is derived from the combination of three indicators of sustainability (ecological, economic, and social). Results show that the level of sustainability is moderate. It was also found that there is a positive and significant relationship between the farmers technical characteristics, the extensional education activities, total sustainability, the authorized use amount of disinfectants, the number of in-service training courses, the temperature of water entering the farm, the number of training courses prior to the activity and the water cost, totally explained of 44. 3% of the total variations in depended variable. In order to sustainability increase of these farms, training courses about nutrition management, cost management, disinfectant management, fish farming cooperatives, and the technical considerations of fishery experts are recommended.