Introduction: In the recent decades, mismanagement, human activities and climatic conditions developed a new view of Iran ecosystems, called desertification. Life cycle assessment (LCA) is a method to construct environmental profile of production systems. That was developed by industrial instruments, but in recent years it is applied by agricultural production process as well. Today, it is acknowledged that land use should be assessed by LCA, but there is still no consensus on the parameters for assessment. In order to assess such land use impact, it is initially necessary to define the variables in the LCI. Once the inventory data is gathered, the LCI results have to be characterized in the impact assessment phase. The main framework of LCA is based on the "from cradle to grave" where we are able to evaluate environmental impacts truly from start point to the end. In this way, we can use the theory of LCA to assess desertification indicators and estimation of ecosystem resistance to this phenomenon. Thus, in this research an LCA approach was applied for estimate ecosystem susceptibility to desertification.....