Introduction: One of the most common problems after implant treatment is peri-implant disease. Recognizing the prevalence of peri-implant disease has a significant role in reducing unwanted complications after implant placement. The purpose of this study was to determine the prevalence of peri-implant disease in patient referring to periodontics department of Yazd Dental School. Materials & Methods: In this cross-sectional study, for patients who have been placed the implant in the periodontics department of dental school in the period of six years, clinical examination and patient records done. Finally, the data were analyzed by SPSS 18 software and Chi-square statistical test. Results: In this study there was a significant relationship between healthy group and periimplantitis in the terms of gender (p value = 0. 047). but there is no significant relationship between age groups (p value = 0. 385). There is a significant relationship between systemic disease (p value = 0. 071), probing depth (p value = 0. 0001), presence of keratinized mucosa (p value = 0. 001) and smoking (p value = 0. 036) with peri-implantitis. This relationship is not significant in the plaque index variable (p value = 0. 229). There is significant relationship between implant type and periimplantitis (p value = 0. 030), but there is no significant correlation for implant location (0. 872), prosthesis type (0. 678), implant method (0. 367). There is direct relationship between the date of implant placement (p value = 0. 01, rs = 0. 229) and implant diameter (p value = 0. 927, rs = 0. 08) with peri-implantitis and inverse relationship between implant length (p value = 0. 296, rs = 0. 046) and peri-implantitis, which is statistically significant only in date of implant placement variable. Conclusion: Based on our data, prevalence of peri-implantitis in patients referred to periodontics department was 84. 9%. Statistically significant relationship was shown between gender, systemic disease, probing depth, keratinized mucosa, smoking, implant type, bridge and date of implant placement and peri-implantitis.