The most important parts of any country's national security, are water and food security. The purpose of this study was to produce and design a toxicological system of water using fish, to protect the drinking water resources and to determine its sensitivity against three types of toxins. In this system, always a sample of water is biologically monitored. The calculations were done by trial and error iterations on two different fish species (tiger barb and tetravirus). As a result, tiger barb fish was introduced as the most appropriate type of fish for using in this system. Also two laser plates were used as transmitter and receiver for electronic parts of the system. The results showed that after entering the toxin into the system, with using tiger barb fish, the alert time of system for concentration of Cyanide (5 ppm) 5 minute and for tree different concentrations of 2, 4-D+MCPA herbicide (17. 4, 23. 2, 34. 8 g/l) would be 520, 280, 100 seconds and also for tree different concentrations of Deltamethrin herbicide (0. 46, 0. 93, 1. 99 g/l) would be 220, 160, 60 seconds respectively. These results demonstrate the effectiveness of the system. The performance of the system and its results shows that the use of this system can helps so much in passive defense, maintaining the health of the country's water supplies and preventing terrorism attacks.