This study aimed to investigate the use of cellulose nanofibers and starch-nano-cellulosepolyacrylamide-nano-cellulose hybrid systems to replace the imported long chemical fibers in the production of durable papers. In this study, imported long fiber chemical pulp was added to cotton pulp at 4 levels. Cellulose nanofibers were added to cotton pulp at 5% level as one treatment and other treatment were designed adding either 1% starch or 0. 1% with polyacrylamide to 5% nano-cellulose having another two treatments. Then another set of treatment using three levels of cationic starch (0. 5, 1, 1. 5%) and three levels of cationic polyacrylamide (0. 05, 0. 1, 0. 15%) were used. From each treatment, 60 gm-2 handsheet were made and the physical, mechanical and optical properties of handsheets from different treated pulps were measured and compared. The results showed that handsheets with increasing nanocellulose alone as compared to imported long fibers, showed increased surface smoothness, tensile strength, burst strength, tear but air resistance, folding resistance and opacity were decreased. Increasing nanocellulose in combination with cationic polyacrylamide increased the paper air resistance, surface smoothness, tensile, burst, tear, and folding strength compared to imported long fibers, and air resistance and opacity decreased. With the increase of nanocellulose in combination with cationic starch, surface smoothness, tensile strength, burst strength, and folding increased but opacity decreased. FE-SEM results also showed that with increasing percentage of cellulose nanofibers, the pores decreased significantly. As a result of the addition of 5% cellulose nanofibers the surface of the paper is smoother and the pores are filled relatively, confirming the results of surface smoothness and air resistance measurement.