SAREM JOURNAL OF MEDICAL RESEARCH (SAREM JOURNAL OF REPRODUCTIVE MEDICINE)
Year:2019 | Volume:4 | Issue:1|Papers Count:8

Producing and collecting the data is significantly increased in the world, in the last two decades, so, the volume of information and knowledge has considerably improved. This process requires a complicated process of separation, introducing, accumulation with convenience and speed of use as the main and complete factors that can provide an appropriate basis of science. So the factors such as the use of barcode for commercial products, computer usage for business, Science Technologies, services and informing the public can have significant and meaningful correlation with technology (from collecting data tools, to text scanning and pictures scanning for data processing to remote sensing satellite). It should be noted that public use of web and internet as a global notification system help us to obtain many information. As a result, the need for new technology and automated tools have been increased and the use of intelligent technology can be help us to easy access to Information and turning data into knowledge and science. Data mining can solves this issue and developed the knowledge that is stored in the large databases. Data mining Takes advantage of several scientific fields such as; databases technologies, artificial intelligence, machine learning, neural networks, statistics, pattern recognition, knowledge-based systems, gaining of knowledge, information retrieval, high-speed computing and visual representation. Data mining in the medical health field In this field, the mentioned process become popularize by some other sciences such that data extraction from patient records and medical records dataset, could lead to the identification of the disease progression and causes and provided valuable information to the experts in order to identify the causes of the disease, diagnosis, prevention and treatment with regards to environmental factors which enhanced lifetime of the people. The most important available services provided by data mining methods in these fields. EHR (Electronic Health Records) established by data mining in Sarem hospital to access to patient information easily and prevent archive space loss and prevent wrong data entering and also provide basis for related activities, such activities include-Evaluation of the effectiveness of treatment (Such as assessing the impact of drugs and their side effects)-Health Management-Customer relationship management-Diagnosis and prevention of the disease (such as diagnosis and prevention of the various types of cancer and chronic diseases)-fraud detection-medical images analysis and-evidence based medicine.

Aims Streptococcus agalactiae strains or group B streptococci (GBS) are the natural flora of the anogenital area of women and are the most important cause of death in the first week of infant birth. The aim of this study was to investigate the isolated strains of group B streptococci and phenotypic resistance pattern of clindamycin induced in pregnant women. Materials & Methods This cross sectional-descriptive study was done on vaginal culture of 861 pregnant women. After a physical examination by a gynecologist, two vaginal swabs of vaginal discharges were taken in 1ml sterile normal saline tube and two slides were delivered to hospital laboratory for staining. The Specimens were cultured on Sheep blood agar, Eosinmethylene blue (EMB) agar and Sabouraud dextrose agar at 35± 1Ċ and Chocolate agar were incubated in candle jar at the same temperature. After diagnostic tests, GBS was isolated and microbial susceptibility test was performed. Also, the Erythromycin-inducible resistances to clindamycin was measured by phenotypic D-test for the samples. Findings Of the 861 samples sent to the laboratory, 141 cases (16. 38%) were positive for GBS. The sensitivity of GBS isolates to penicillin, cefalexin, and ceftazidime was 98. 58%, 97. 8% and 98. 88%, respectively. There was no resistance to ampicillin and ceftriaxone in the samples, but 2. 84% of them were resistant to ciprofloxacin. Clindamycin induced resistance was positive in 14. 89% of pregnant women. Conclusion Among isolated bacteria, 16. 38% of them are part of group B streptococci that 14. 89% of them are clindamycin induced resistance and 38. 6% of them have concurrent resistance to erythromycin and clindamycin.

Aims Mother-to-child transmission of Toxoplasma (Toxo), Rubella, cytomegalovirus (CMV) and varicella zoster virus (VZV) can lead to severe birth defects and even the death of the infant. Therefore, evaluation of women’ s immunity in childbearing age is necessary for vaccination and to prevent these infections. The aim of this study was to investigate the seroepidemiology of Toxoplasma, Rubella, CMV and VZV in women. Materials & Methods The present study is routine data base study. The results of prepregnancy tests were recorded and analyzed in the second half of 1995 in Sarem Women’ s Hospital. Findings Toxo IgM tests were negative in 972 (99. 7%) patients and only 0. 3% were positive. Toxo IgG tests were negative in 97% of subjects and 3% of them. Rubella IgG test was positive in 757 cases (86. 5%) and negative in 118 cases (13. 5%). Rubella IgM tests were negative in all subjects who performed the test. CMV IgM tests were negative in 99. 8% and only 0. 2% were positive. The IgG CMV test was positive in 86. 8% of patients. VZV IgM was reported in all negative cases, but VZV IgG was positive in 98. 5% and negative in 1. 5%. The mean age of positive cases versus negative cases except Toxo IgG did not show any significant difference (p>0/05). Conclusion 99. 7% of women were seronegative for Toxo IgM, 99. 8% for CMV IgM and all of them for Rubella IgM and VZV IgM. Also, 97% of the patients were seropositive for Toxo IgG, 86. 5% for Rubella IgG, 86. 8% for the CMV IgG test and 98. 5% for the VZV IgG test.

Aims In the recent years, Advances in science and technology have decreased the mortality rate of premature infants significantly. Nevertheless, 70% of neonatal deaths still have a direct correlation with prematurity. It seems that updated statistics of mortality and morbidity rate of very low birth weight infants (VLBW) are necessary for proper planning. Although the mortality and morbidity rates of premature infants have been studied in many countries, there are few studies in this field in Iran. Therefore, this study was done to determine the mortality rate of neonates weighing less than 1500 grams. Materials & Methods This retrospective cohort study was done in 138 premature infants with intrauterine age more than 24 weeks and birth weigh less than 1500 grams. These infants have been hospitalized in neonatal intensive care unit (NICU) of Sarem women’ s Hospital during the years 1388-1395. Findings The mean birth weight of these infants was 1077. 00± 287. 00 g and the mean gestational age was 28. 90± 3. 00 weeks. The survival rate was 78. 3% in this group. The highest survival rate was in the group of infants weighing 1500-1000 g and 90% of them were discharged from the hospital. The neonatal mortality rate increased with birth weight loss, so that in infants weighing less than 700 g survival rate was 27. 8%. Conclusion The mortality rate of infants increases with birth weight loss. In addition, the gestational age and apgar score of the fifth minute are related to neonatal mortality.

Aims Pre-eclampsia is one of the major cause of maternal mortality and morbidity. The aim of this study was to investigate epidemiological and fetal and maternal complications in preeclamptic patients. Materials & Methods The files of 195 patients with pre-eclampsia who were admitted to the Sarem hospital from 2010 to 2015 were investigated and information was recorded in the preprepared checklist. Findings Of the total patients, 63. 9% were asymptomatic, such as loss of consciousness, epigastric pain, headache and seizure. There was no case of maternal death and only one case of intrauterine fetal death (IUFD) was available in the records. Maternal complications were observed in patients. Fetal complications were observed in 26. 2% of patients. Antiphospholipid syndrome was observed in 3. 1% of patients with maternal complications compared to 1% of uncomplicated mothers (p=0. 001). Serum glutamic-oxaloacetic transaminase (SGOT) mean was 49. 5 in mothers with complications and 26. 94 in mothers without complications (p=0. 043). Serum glutamic-pyruvic transaminase (SGPT) mean was 60. 13 in mothers with complications compared to 23. 87 in uncomplicated mothers (p=0. 001). Lactate dehydrogenase (LDH) mean was 2235. 38 in mothers with complications and 735. 02 in mothers without complications. In patients with fetal complications LDH levels were 385. 35 and in cases without fetal complications 375. 02. Conclusion The level of liver enzymes and the presence of antiphospholipid syndrome are considered as predictors of maternal complications, while lactate dehydrogenase and signaling in the mother predict maternal and fetal complications.

Aims One of the most common diseases of the uterus is myoma (leiomyoma or fibroma). Fibromas can grow in different parts of the uterus with different sizes. Fibroids are benign and only 20-25% of the cases are symptomatic and their treatment can include follow-up, patient monitoring, drug treatment, or surgery. In this study, a patient with the pedunculated submucosal myoma with a preservation of virginity was reported. Patient & Methods This study is a case report that was done in 2017. A 35-year-old single woman with severe vaginal bleeding and vaginal mass was referred to the Sarem women’ s hospital. Due to the virginity of the patient and the religious beliefs about virginity, it was decided to go laparotomy to myoma exit, since the vaginal exit of the mass resulted in damage to hymen. Conclusion For the treatment of submocusal myoma with preservation of hymen can be used to an abdominal surgery and laparotomy.

Aims Unicornuate uterus is one of the congenital anomalies of female reproductive system causing many important complications such as hematometra, endometriosis, torsion and ectopic pregnancy. Endometrial cavity in the rudimentary horn and small cavity of the uterus are the most important causes of these complications. Between referring to gynecologic clinics in emergency situations such as abortion, preterm labor, extra-uterus pregnancy, and in non-emergency such as infertility and endometriosis, there are many abnormalities in the reproductive system, some of which are associated with abnormalities in the urinary system; Therefore, trying to treat the uterus greatly resolves one of the problems of obstetrics and gynecology. In this study, a new method of coronoplasty surgery was introduced in the unicornuate uterus with the rudimentary horn. Patient & Methods This study is a case report that was done in 2013. A 22-year-old woman referred to sarem women’ s hospital for secondary infertility and undergoing diagnostic laparoscopy and the surgeon realized the unicornuate uterus with the rudimentary horn. In this patient, the rudimentary horn was not cut off and during a new surgical procedure called coronoplasty, the rudimentary horn was connected to the uterus major horn and was reconstructed as a larger uterus. Conclusion Coronoplasty is novel and effective surgery method for reconstruction of unicornuate uterus with rudimentary horn.

Aims Alterations of Th17 cells during pregnancy have a crucial role in maintenance of fetus and the high level of these cells has been observed in women with recurrent spontaneous abortion. Immunotherapy with paternal lymphocytes is one of the effective therapeutic methods for this complication. The aim of this study was to evaluate the alteration in Th17 cytokine levels in patients with recurrent abortion after lymphocyte immunotherapy. Materials & Methods In this semi-experimental study, 30 patients referred to Sarem hospital with a history of at least three recurrent abortions in 2013 were evaluated. The levels of IL-17and IL-21 in patient serum and supernatant of cultured peripheral blood mononuclear cells were assayed before and after this treatment by using ELISA. Statistical analysis was performed with Wilcoxon test by SPSS 22. Findings The levels of IL-17and IL-21 in patient serum after immunotherapy were significantly decreased (p<0. 05). Supernatant of cultured peripheral blood mononuclear cells after immunotherapy showed a low level of IL-21 (p<0. 04), while this change was not significant for interleukin 17 (p=0. 13). Conclusion Lymphocyte immunotherapy reduces the level of pro-inflammatory cytokines of Th17 cells in women with recurrent spontaneous abortion.