As a psychopathology, nomophobia, is the consequences of excessive use of smartphones, although its pathological aspects are not yet clear. The present study aimed to identify the psychopathological profile of nomophobic individuals. The research methodology was descriptive-comparison. A sample of 323 people was selected from among the students of Semnan University based on the cut-off point scores and was placed in three groups of severe, moderate, and mild nomophobia. The instruments included Symptom Checklist-Revised and Nomophobia Questionnaire. Descriptive statistics, multivariate analysis of variance, and Scheffe post hoc tests were used to analyze the data. The results showed that in all 9 symptoms of SCL-90, the average score of people with severe nomophobia was higher than individuals with mild nomophobia. Similar results were obtained in groups with severe and moderate nomophobia, with the exception of two symptoms: somatization and phobia. Considering the psychopathological profile of people with severe nomophobia, it was found that the severity of psychological damage in this group was significantly higher in the symptoms of paranoid thoughts, depression, interpersonal sensitivity, obsession, and psychosis, respectively. The results provide a comprehensive picture of the psychopathologies associated with nomophobia, based on which intervention or research orientations in the field can be guided more effectively.