Journal of Inflammatory Diseases
Year:2018 | Volume:22 | Issue:3 (98) |Papers Count:12

Background: PPAR-g and PRDM16 proteins have key role in the metabolism of adipose tissue and the conversion of white tissue to brown adipose tissue. But, the role of exercise on these two important proteins has not been studied in subcutaneous adipose tissue.Objective: The aim of this study was to investigate the effect of continuous training on the level of PPAR-g and PRDM16 proteins in the adipose tissue in overweight male Sprague- Dawley rats with diabetes.Methods: In this study, 16 two-month old Sprague- Dawley rats with an average weight of 270±20 g were selected and randomly divided into two groups: control (n=8) and continuous training (n=8).The training group exercised according to the training program 4 days a week for 8 weeks while the control group did not have a training program. Independent t-test was used to analyze the data.Findings: There was a significant increase in the expression of PPAR-g (P=0.004) and PRDM16 (P=0.0001) proteins in the training group compared to control group.Conclusion: Considering the increase of PPAR-g and PRDM16 proteins in adipose tissue after continuous exercise and the important role of these two proteins in the fat metabolism, aerobic exercise can be an important mechanism for reducing this tissue in obese individuals and converting white tissue to brown.

Background: Chronic sinusitis is defined as a symptomatic inflammation of the paranasal sinuses for at least 12 weeks. Many risk factors such as genetic malformations, allergic rhinitis, gastro esophageal reflux, exposure to cigarette smoke and anatomical variations play a role in chronic sinusitis. In numerous studies nasal cavity anatomical variations are introduced as one of the most important risk factors for chronic sinusitis.Objective: The aim of this study was to determine the association between the anatomical variations in paranasal cavities and chronic sinusitis.Methods: This cross-sectional study was performed on 218 suspected participants (over 18 years old) to chronic sinusitis who were referred to the infectious diseases clinic of Bu-Ali Sina Hospital, Qazvin from 2015-2016. According to the positive or negative confirmation of sinusitis in the CT scan, patients allocated into two groups and the prevalence of underlying characteristics and anatomical variations were compared.Findings: Sinusitis was confirmed by CT scan in 103 (47.2%) participants. There was significant statistical correlation between sinusitis and closed osteomeatal complex and concha bollosa (P=0.001 and 0.01 respectively), but the correlation between sinusitis and septal deviation, paradoxical curvature of the middle turbinate, agger nasi and haller cells was not statistically significant.Conclusion: A significant statistical correlation was observed between chronic sinusitis and the presence of some anatomical variations of the nasal cavities such as closed osteomeatal complex and agger nasi cells. Alterations in sinus drainage and ventilation dysfunction may considered to play a role in this correlation.

Background: There is a relationship between nutrition pattern and sleep status. The role of demographic and dietary factors on the sleep quality in Iranian children are unclear.Objective: To determine the sleep pattern in children aged 7-12 years and its relationship with demographic factors and dietary pattern.Methods: In this cross- sectional study, 264 students aged 7-12 years old were invited using multistage random sampling from schools of Qazvin in 2015-2016. The Children's Sleep Habits Questionnaire (CSHQ) and 24-hour diet-recalls questionnaire were used to determine the sleep pattern and dietary pattern, respectively.Findings: The mean age of the subjects was 9.5±1.53 years. The prevalence of sleep disturbances (CSHQ score>41) was 77.5%. There was no significant relationship between 4 macro-nutritious types (fat, protein, carbohydrates and energy) with sleep pattern and its subscales. There was a significant relationship between bedtime resistances with mother education; sleep onset delay with weight and school grade; sleep anxiety with father education, weight and sex; frequent night waking, parasomnia, and sleep disordered breathing with sex and father education.Conclusion: The prevalence of sleep disturbances was high in our study. Although there was no relationship between dietary pattern and sleep pattern, but sleep pattern was significantly associated with demographic factors. Therefore, it is recommended that programs should be developed to raise awareness in communities, focusing towards parents.

Background: The population of the elderly has grown in recent years in the world and similarly in Iran.Objective: The aim of this study was to investigate the impact of counseling on the elderly women’s family and raising their awareness about the elder abuse.Methods: This clinical trial study was conducted from August to December 2017 in the health centers of Shahiryar, Tehran Province. Sixty five elderly women were selected by convenient sampling. Then, their first grade families were randomly assigned to two groups: intervention (n=34) and control (n=31). The intervention group received four sessions based on transtheoretical model. Modified questionnaire was evaluated elder abuse and the data analyzed by Pearson chi- square.Findings: The findings showed that counseling sessions, according to the transtheatrical model, can cause a significant reduction in negligence (P<0.005), psychological abuse (P=0.006) and financial harassment (P<0.005)in elderly women’s family. None of the elderly reported any physical abuse.Conclusion: The results showed that counseling based on transtheoretical model could be effective on raising awareness of the elderly women’s family. It is proposed to create a program of counseling for families, elderly women and increase sensitivity of this phenomenon.

Background: Spiritual intelligence as a basis of individual beliefs plays a fundamental role in various areas of human life, especially mental health promotion.Objective: This study investigated the relationship between spiritual intelligence and perceived stress among critical care nurses.Methods: This descriptive- analytical study was carried out on 115 nurses who were selected by nonrandom sampling method in a correlation manner. Data were gathered by using three questionnaires: demographic information, king's spiritual intelligence and Cohen's perceived stress questionnaire and analyzed by linear regression and correlation coefficient analysis.Findings: In this study 13 men and 102 women participated. The mean score of perceived stress (25.7±5.96) and spiritual intelligence score (50.28±14.35) were moderate. There was a reverse and significant relationship between spiritual intelligence and its subscales with perceived stress (r=-0.243 and P=0.009). The study showed that spiritual intelligence and education level can be considered as predictive variables for perceived stress (P<0.001).Conclusion: Considering the significant relationship between spiritual intelligence and perceived stress and the predictive role of spiritual intelligence, one of the effective strategies in reducing stress can be shifting the attention of nurses towards spiritual intelligence and attempt to promote it.

Background: Spiritual well- being is considered as an important aspect of heath. It plays an important role in the development of health outcomes.Objective: This study was conducted to investigate the statues of spiritual well-being of student of Qazvin University of Medical Sciences as the health care providers.Methods: This descriptive- analytical study was conducted on 307 students which selected from Qazvin University of Medical Science by multi-stage sampling in 2019. The data were collected using Ellison and Paloutzian 20-items spiritual well-being questionnaire. The reliability of questionnaire was examined through cronbach's coefficient alpha approach. Data were analyzed using independent t-test and ANOVA.Findings: The results showed that the mean of religious well- being was 36.20±6.84, existential wellbeing 34.59±5.82 and total spiritual scores were moderate (70.78±11.33). Significant relationships were found between spiritual well- being and field of study (P<0.001), level of study (P=0.004), and housing conditions (P<0.001).Conclusion: According to the findings, the level of spiritual well- being among students was moderate which was related to their field, level of study and housing conditions. Due to the impact of these results on the health outcomes of the community, it should stimulate discussion about the necessity of planning to improve the level of students' spiritual well-being according to their demographic variables.

Background: Research is one of essential elements for development of each country and is a pioneer and precursor in providing accurate and making decision.Objective: This study evaluated the results of comprehensive health plan projects of Qazvin University of Medical Sciences from 2009 to 2013.Methods: This descriptive- analytical study was performed in four steps. The first two steps included the formation of a leadership team and holding of meetings with representatives of 22 executive authorities of the province. The third step included the compilation of the executive proposals of each organization and fourth step, received final reports and evaluations. In each step, a variety of methods were used for data collection, including reviewing all the documents, expert panel, focused group discussion and stakeholder analysis, Delphi technic and nominating group.Findings: From 43 conducted projects, only 31 projects (72%) were completed by Qazvin University of Medical Sciences. As the results, projects were in the field of policy documents (n=10), regulation (n=1), educational packages (n=4), educational programs (n=5), health index (n=1), models (n=7) and applications (n=18).Conclusion: Some of the defined projects were essential in 2010 and their implementation could solve some of health problems of the province. It seems that implementation joint projects could solve complex and multi-dimensional problems by promoting and applying intersectoral collaboration between health sector and executive authorities of the province.

Background: The fitness of laptop desks (sitting cross-legged) with physical dimensions of users have important role in using with correct posture and reduce the prevalence of musculoskeletal disorders.Objective: The aim of this study was to evaluate the fitness of anthropometric dimensions of students with best-selling laptop desks.Methods: In this study, 207 students (girls and boys) from Qazvin University of Medical Sciences were investigated. In addition to height and weight, anthropometric dimensions including; elbow height (sitting), elbow- elbow breadth, two knee length and height (sitting position cross- legged) and elbow-fingertips length were measured. Then percent of the fitness between the laptop desks with anthropometric dimensions obtained.Findings: The results showed that the two types of laptops desks fit only in the length of the desk. Two knee length and height (sitting position cross-legged), elbow- fingertips length and elbow height (sitting) fit in the desk number one 32.4, 98.5, 0, and 93.7% and in the desk number two 61.8, 0.96, 0.5, and 78.3% respectively.Conclusion: It had a 100% fitness only in length of the table with anthropometric dimensions of students between two types of laptop desks. However in terms of fitness, the desk number one with the highest percentage in three anthropometric dimensions was better than the desk number two.

In recent years, knowledge of the biology of stem cell has been very effective and the precise and proper regulation of stem cell function are important for their bio-activity. Several main signaling pathways have roles in regulating them including Wnt/ b-catenin, and Hedgehog which mediate different stem cell properties including self-renewal, survival, proliferation, and differentiation. Also, molecular structures such as microRNAs act as tumor inhibitors or oncogenes and will change the direction of the messenger. The purpose of this review is to find and introduce different signaling pathways involved in controlling cancer stem cells with cancer treatment goals. The search was conducted using several databases including Google Scholar, PubMed, Scopus, Science Direct and totally 93 papers were selected.It seems that very important signaling pathways have been disturbed in cancers and excessive or abnormal signaling through these pathways can contribute to the survival of stem cells. Many of these pathways are not direct, but as an interconnected network of signaling could feed each other. Better therapeutic goals can be achieved with understanding signaling pathways involved in cancer stem cells and drug resistance.

Background: Pyogenic granuloma is a common tumor like growth of the oral cavity that has been considered to be non- neoplastic in nature and a reactive lesion.Objective: This study aimed to investigate the prevalence of pyogenic granuloma lesion in pathology Department of Tabriz Dental School between years 2006-2016.Methods: In this cross-sectional study, 1081 clinical records were analyzed.Findings: Eighty- two patients, 36 (43.9%) male and 46 (56.1%) female with pyogenic granuloma were identified. Most of patients (26.8%) were in the second decade of life. The frequency of this lesion was highest in the gingiva area (57.8%) and lowest in the lip and buccal mucosa (3.7%).Conclusion: Results showed that between years of study, 82 cases of pyogenic granuloma has been recorded. Prevalence of this lesions was higher in women and in second decade of life. Most of the lesions were in the gingival area.