Background & Aim: Spinal cord injured men (SCI), besides ejaculatory dysfunction, suffer from poor semen quality. Among different possible causes, Recent investigations suggest the negative role of seminal plasma constituents on sperm quality. We compared the seminal plasma Zinc concentration as a prostatic secretary marker in SCI men and normospermic controls.Materials & Methods: The study included 30 SCI men (mean age 36±2.3 years) and 30 noninjured normospermic men (mean age 34±3.2 years). After 3 days abstinence, Fasting blood and semen samples were obtained (antegrade portion of electroejaculatein SCI men). Sperm parameters, seminal pH and seminal plasma osmolality were measured.Serum and Seminal plasma Zn2+ concentrations were measured by flame atomic absorption spectrophotometry.Results: Mean seminal plasma Zn2+ concentrations were (120.74±42.9 and 156.88±49.9 mg/l, Pvalue<0.05) in SCI men and normospermic men respectively. serum zinc concentrations were (1.62±1.23 and 2.01±0.8 mg/l respectively, Pvalue>0.05). Seminal PH and osmolality were (7.87 ±0.23 and 322.4±1.2 vs 7.58±0.26 and 382.5±21.1 respectively, Pvalue<0.05). seminal plasma Zn2+ concentration was correlate with sperm count (r=-0.277, Pvalue<0.05), viability (r=0.404, Pvalue<0.05), normal morphology(r=.332, Pvalue<0.05), total motility (r=0.422, Pvalue<0.05) progressive motility (r=.386, Pvalue<0.05) significantly, Seminal pH (r=0.39, Pvalue<0.05) and Seminal plasma osmolality (r=0.474 Pvalue<0.05).Conclusion: Our findings indicate decreased seminal plasma zinc concentration and osmolality, and increased seminal pH, in SCI men compare to normospermic controls. These findings may indicate the prostatic secretory disfunction following SCL that can be the couse of poor semen quality in this patients.