Introduction: Although the coronary artery aneurysms (CAA) are common, giant aneurysms are rare. Clinical presentation, prognosis and management of giant CAA are not well defined due to a limited experience. Recently, there are increasing reports suggesting the occurrence of CAA as a complication of drug eluting stent implantation and angioplasty. The majority are atherosclerotic in origin. Other causes include connective tissue disorders, trauma, vasculitis, congenital, mycotic and idiopathic. The primary complication is myocardial ischemia or infarction, with rupture being rare. Treatment options include anticoagulation, custom made covered stents, reconstruction, resection, and exclusion with bypass.Case Presentation: A 51 year-old man was referred for autopsy, Findings in autopsy: Finding front of a heart 10×10 centimeter saccular aneurysm, originating from the right coronary artery , heart larger than normal size (460 g), calcification, atherosclerosis & stenosis in all coronary artery ,calcification in heart valve, old ischemia in left ventricle. Findings in microscopy: Infiltration hemorrhage & clot in RCA and aneurysm. There were associated calcification and severe stenosis of the RCA, LM & LAD. The past medical history was unclear, but smoking is noted.Conclusion: Right coronary artery aneurysms in adult patients are predominantly atherosclerotic in origin. The clinical presentation is due to myocardial ischemia, likely from associated embolism. Rupture is rare. Operative treatment is exclusion and revascularization.