Hormozgan Medical Journal
Year:2018 | Volume:22 | Issue:1 |Papers Count:11

Introduction: Chronic vascular inflammatory state plays an important role in the pathophysiology of thalassemia. Cross-sectional studies suggest that exercise has anti-inflammatory effects, leading to lower levels of several proatherogenic inflammatory markers. However, this has yet to be confirmed by randomized prospective trials. The present pilot study examined the effect of Concurrent) Training on inflammatory markers of Beta Thalassemia Major Patients.Methods: In this semi-experimental study, 18 patients with Beta Thalassemia major were selected as convenient samples and voluntarily divided in two groups: experimental (n=9) and control group (n=9). The subjects of the experimental group attended the concurrent (Resistance-Endurance) Training for eight weeks (3 Sessions per week and each sessions 90 min). Subjects' blood samples were taken before and after training protocol in order to measurement hs-CRP, IL-6, IL-1b andIL-12 Serum levels. The levels of these markers were measured by using an enzyme-linked Electro immune assay (ELISA) kits. For data analysis the Repeated measures ANOVA, was used. All statistical analysis was performed by SPSS software (V.19). The level of significance was considered P<0.05.Results: The results indicated reduction of HS-CRP and IL-6 after eight weeks of concurrent training compared to the control group (P<0.05), but IL-1b and IL-12 was increased in training group (P<0.05).Conclusion: The reduction of HS-CRP and IL-6serum level and its natural range in the exercise protocol, can be a regulating response to inflammatory condition in patients under certain exercise conditions without any pathological importance and maybe improved chronic vascular inflammation. We demonstrated that concurrent (resistance-endurance) training is inversely correlated with levels of pro-inflammatory markers in Beta Thalassemia major patients, possibly retarding the process of atherosclerosis and results showed that immune modulation.

Introduction: The angiotensin 1-7 (Ang1-7) Mas receptor (MasR) axis, bradykinin (BK) and female sex hormone are involved in releasing of vasodilatory biomarkers including Nitric Oxide (NO). We examined the role of MasR and BK on NO metabolite (nitrite) production response to Ang 1-7 infusion in ovariectomized rats treated with estradiol.Methods: A total of 48 female Wistar rats were divided into 2 main groups; ovariectomized treated with placebo (OVX) and ovariectomized treated with estradiol valerate (OVE) for period of two weeks. Then after anesthetization, the animals of each groups were divided into four subgroups that received MasR antagonist (A779) or, BK, BK+A779 or vehicle, and they were subjected to Ang1-7 infusion(0, 100, 300 and 1000 ng/kg/min). The level of nitrite (NO metabolite) was measured by Griess method.Results: The serum level of nitrite response to Ang 1-7 administration in OVE group was incrased when compared with OVX group, however when MasR was blocked by A799, the increased nitrite level was abolished. BK also increased the level of nitrite but co administration of BK and A779 did not enhance the nitrite level in both OVE and OVX groups.Conclusion: Estradiol and Bk increase nitrite production in response to Ang 1-7 infusion in condition of MasR presence.

Introduction: The production of Reaction Oxygen Species (ROS), lowers cellular antioxidant levels, and enhances oxidative stress in many tissues, especially the liver. Efficient liver function is extremely important to the overall health. The key to helping prevent long-term damage is to decrease oxidative stress. The purpose of this study was to assess the effects of treadmill training with vitamin C or estradiol on nitric oxide metabolite, oxidative stress marker and liver enzymes levels in female rat.Methods: Thirty two female rats were randomly divided into four groups of 8 rats each; consisting of control (Con), training (Tr), training+vitamin C (Tr+VitC), and training+estradiol (Tr+Es) groups. Vitamin C (250 mg/kg/day) was injected three times a week for 6 weeks, and estradiol (0.25 mg/kg/week) was injected for the two first weeks. Training groups performed aerobic exercise on a treadmill 5 days/week for 6 weeks. Serum and liver tissue levels of nitrite and malondialdehyde (MDA), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in serum were determined.Results: The results showed significant reductions in the serum nitrite in Tr+VitC group (6.33±0.37mmole/l) compared with Con group (9.67 ± 1.39 mmole/l) and Tr group (9.91±1.33 mmole/l) groups. While Tr group (0.22±0.02 mmole/l) exhibited lower liver nitrite compared with Con group (0.29±0.01 mmole/l) group. Serum MDA in Tr (6.68±0.31mmole/l) and Tr+VitC (7.01±0.44 mmole/l) groups was significantly higher than in Con groups (5.20± 0.40 mmole/l).Conclusion: Our findings indicate that the treadmill training program used in this study was able to attenuate the liver oxidative stress but administration of vitamin C or estradiol couldn’t improve liver status.

Introduction: Gestational diabetes is a common problem in pregnancy that affects about 7% of pregnancies. The high intake of iron intake is associated with an increased risk of type 2 diabetes in the general population. The purpose of this study was to determine the association between total iron intake (diet and supplement) and gestational diabetes.Methods: This is a one-year prospective cohort study.120 pregnant women referred to rural health centers in Bandar Abbas, Hormozgan, Iran were enrolled in the study. The data were collected using a checklist, food frequency questionnaire (FFQ) questionnaire for measurement of iron intake through food. Demographic data was presented as mean±SD or number (%) and final results were presented with Odds Ratio (OR) with 95% confidence interval.Results: The findings showed that hemoglobin level in 6-10 (OR: 2.62 CI: 1.42-4.39) and 24 to 28 weeks (OR: 2.9 CI: 1.43-4.02), the amount of iron intake from the beginning of the pregnancy from 6 to 10 (OR: 2.81 CI: 1.28-3.98) and 16-20 weeks of pregnancy (OR: 2.94 CI: 1.35-5.43) as well as, the amount of iron supplemental ingestion (OR: 2.83 CI: 1.39-4.54) are the most important predictors of GDM.Conclusion: According to the findings of this study and the current national guidelines for the administration of routine iron to all pregnant women, increasing the level of iron by supplement and subsequent increased risk of GDM should be more considered.

Introduction: Parasitic diseases and infections remain a significant cause of morbidity and mortality in the developing countries all over the world. Gaining data about parasitic infection is necessary to contrive suitable control programs and strategies to prevention and that is main aim of this study. This study evaluated frequency of intestinal parasites in Milad hospital, Tehran, Iran.Methods: During 2015-2016 about 13385 stools and 343 scotch tape samples were collected in Tehran. All specimens examined by direct smear and formalin- ethyl acetate concentration methods. All stool samples were well analyzed to diagnose any proglottids or mature helminthes that can be seen in stool in some conditions. Scotch tape method is an appropriate way to detect parasitic nematode ofEnterobious vermicularis.Results: Data showed that 2.7% of cases had at least one parasite in examination. Frequency of parasites reported asB.hominis (1.3%), G.lamblia (0.8%), E.nana (0.3%), E.coli(0.3%), Taenia and C.mesnili (0.1%, 0.1%). Six cases of 343 scotch tape samples were positive for pinworm.Conclusion: Due to high standards of public health in Tehran, frequency of intestinal parasites is lower than other studies conducted in other regions. Demographic, socioeconomic characteristics and education can affect transmission of parasites and may involve in lifecycle completion.

Introduction: Parasitic diseases and infections remain a significant cause of morbidity and mortality in the developing countries all over the world. Gaining data about parasitic infection is necessary to contrive suitable control programs and strategies to prevention and that is main aim of this study. This study evaluated frequency of intestinal parasites in Milad hospital, Tehran, Iran.Methods: During 2015-2016 about 13385 stools and 343 scotch tape samples were collected in Tehran. All specimens examined by direct smear and formalin- ethyl acetate concentration methods. All stool samples were well analyzed to diagnose any proglottids or mature helminthes that can be seen in stool in some conditions. Scotch tape method is an appropriate way to detect parasitic nematode of Enterobious vermicularis.Results: Data showed that 2.7% of cases had at least one parasite in examination. Frequency of parasites reported as B. hominis (1.3%), G. lamblia (0.8%), E. nana (0.3%), E. coli(0.3%), Taenia and C. mesnili (0.1%, 0.1%). Six cases of 343 scotch tape samples were positive for pinworm.Conclusion: Due to high standards of public health in Tehran, frequency of intestinal parasites is lower than other studies conducted in other regions. Demographic, socioeconomic characteristics and education can affect transmission of parasites and may involve in lifecycle completion.

Introduction: Rheumatoid arthritis (RA) is a chronic rheumatologic disease, affecting different aspects of patient life. Although several studies have reported a higher rate of depression among patients with RA, there is still controversy over the underlying risk factors and probable covariates of depression in these individuals. The present study investigated the relationship between disease activity, serum levels of vitamin D, and depression in patients with RA.Methods: In this cross sectional study patients with confirmed RA based on the American College of Rheumatology guidelines entered the study. Disease activity was measured using the Disease Activity Score (DAS). The Hospital Anxiety and Depression Scale (HADS) was also administered to determine the subjects’ level of depression. The Health Assessment Questionnaire (HAQ) was applied for evaluating the subjective disability of the patients in their daily activities. Serum levels of vitamin D, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were also measured.Results: 62 patients were enrolled in the study. Depression was present and possibly present in 12 (19.4%) and 15 (24.2%) cases, respectively. According to the results the DAS was inversely associated with vitamin D3 levels (P<0.001). There were also significant relations between the DAS and scores on both the HAQ and HADS. Moreover, higher levels of vitamin D3 were related with lower scores on the HAQ and HADS (P=0.018).Conclusion: Higher scores on the HADS were directly associated with lower levels of vitamin D, HAQ score and disease activity. Nevertheless, no significant association was found with HADS and patients’ sociodemographic characteristics. Targeted approach to psychological aspects and vitamin D levels among patients with RA may have considerable implication for the optimal management of RA.

Introduction: Depression is considered as a disorder that students have a susceptible environment for it and is affected by many factors. Therefore, the purpose of this study was to determine the role of satisfaction of basic psychological needs and family functioning by interdisciplinary role of emotion regulation difficulty in the prediction of depression.Methods: The method used in the study is descriptive approach by structural equation modeling. The sample consisted of 452 (207 boys and 245 girls) students universities Tabriz who were selected using multistage cluster sampling. Then, they filled out depression Questionnaire, satisfaction of basic psychological needs, family Assessment Device and Difficulties in Emotional Regulation Scale. Data were analyzed by using Pearson correlation coefficient, cronbach alpha and structural equation modeling.Results: The results of the study showed that the goodness of fit index (GFI), adjusted goodness of fit index (AGFI), comparative fit index (CFI), is greater than 0.90 and root mean square error of approximation (RMSEA), and root mean square residual (RMR) index is less than 0.05. Therefore, the proposed model has had a very suitable fitness with data. In this study, the most direct effect is the satisfaction of basic psychological needs on depression with a coefficient of -0.38 and satisfaction of basic psychological needs has the most indirect effect through emotion regulation difficulty on depression with a coefficient of -0.12.Conclusion: Based on the results of the present study, it can be concluded that Difficulties in Emotional Regulation As a Mediator of the Relationship between satisfaction of basic psychological needs and family function can explain depression in College Students and, thereby, attention to this matter can lead to the proposal of some recommendations for depression in College Students prevention and treatment.