Pegmatites are one of the most important deposits regarding their vast availability and economical importance in production and mineral processing of industrial minerals. Some of the main constituents of the pegmatite's are feldspars, silica, and micas. The present paper deals with the results of the first part of mineral processing of mica separated from Hamadan regional pegmatite by floatation. The main goal of this part of research is finding the most important factors of the floatation of the prepared mica.For the floatation tests, 2n factorial design tests with four main factors, i.e., collector consumption, pH value, particle size and solid content of the pulp were used. The results of the mica grade were analyzed by Yates statistical technique it has been found that C parameter (particle size), and AD interaction parameter (collector consumption x solid content), regarding the consistency of the variance levels of their effects; show a meaningful effect on the results. These parameters are most important for the floatation of the mica in the pegmatite. In the case of mica recovery, pH (B factor) is the most effective one.