Background and Objective: One of the most significant and important points in Islamic rules and orders is to keep and develop health and it’s emphasize on prevention rather than treatment .The great prophet (pbuh) accounted the life without health and safety as a fruitless and unhealthy life. Since he declare that “ a life without health and safety is not a good life “ . What today health organizations call as: “healthy man is the base of continuous development” is the same as our prophet (Pbuh) said.One of the most important aspect of Islam regulations is considering oral hygiene and toothbrush. Good dental health is more than the absence of disease or tooth decay in mouth.Materials and Methods: The research is a review article that surveys is based on important and standard Islamic resource and the prophet (pbuh) Manner and Instructions.Results: Reviewing Islamic information sources such as: Teboalnabi, Nahjolfasahe,Tebbolaemme, Makaremol akhlagh, Vasaelo–shiate and some other sources show important issues on health and illness prevention , beside the danger of lack of mouth and dental health and its benefits, too. The said sources of Islam Speak and determine the time of brushing, its method, benefits and tooth. Prophet Mohammad said, "Were it not that I might overburden believers, I would have ordered them to use the miswak at every prayer". The Islam prophet said about tooth brushing significance from Gabriel angel that ordered him much for tooth brushing that he said I though it will be a legal order soon. Beside these benefits the Islam order and regulations about health and sanitation are holy too ,this is why two prayers for a Moslem with brushed tooth is more valuable than seventy prayers with non- brushed tooth. The prophet(Pbuh) also indicated that providing a thoot pick is one of the guest right.Conclusion: Considering all the Islamic and prophet orders and deeds on mouth and dental hygiene, its emphasis and following them can somehow retain the body health and finally have a significant role on Islamic society and be a positive model for other societies too.