During the fall of 2000, high death rates were reported among Caspian seals (Phoca caspica), which live only in the Caspian sea and are listed as a vulnerable species by (IUCN).Dead seals, presumably borne on the counter-clockwise current of the Caspian Sea, are frequently washed ashore. The die-off was reported near the mouth of Safid Rood in late April and subsequently reported from other areas in Gilan and Mazandaran provience along 1000 km of coasts of southern Caspian. Therefore census of dead seals conducted. The census fell with in eastern region of coastlines in the provience of Gilan. A total of 58 seal's carcasses were sighted along 28 km transect in 3 sites, each site measured 5 km.Body size and condition of dead seals were analyzed for the cause of death, age and sex. Animal condition measured by the level of blubber deposition, which represent energy and reflected nutritinal status of animals.Postmortem examination and necropsies were carried out on 20 dead seals. Samples of lung, liver, spleen, bladder, stomach, lymph nodes, muscle, blubber, brain, kidney, intestines were taken and fixed in 10 percent formalin for virology, toxicology, serology, histopathology, bacteriology and algal toxins. Blood samples were obtain on three occasions from 3 live seals, also.Further studies are required to determine if the Caspian seals are infected with "Canine Distemper Virus" which genetically similar to that found in the other seals species.The epidemiology of disease including its effects on the Caspian seal population, and level of chemical contaminants in tissues of seals that could have immunotoxic effects in Caspian seals, also remains to be investigated. Shrinkin population of Caspian seals and the conflict between the fisheries and seal safety is becoming more pronanced. Further works is under way to determine whether fisheries operations contribute to the mortality rates of the Caspian seal in southern coasts (Iran).This work was carried out under Ecotoxicolog project "Ecotox", Caspian Environment Program "CEP", founded by the World Bank through a donation by the Japanese Consultant Trust Fund.