In this study, the impact of independent variables including current deposits, investment deposits, saving deposits, long-term investment deposits, short term investment deposits and other deposits on total bank income based on response surface methodology is evaluated. For this purpose, central composite design with 5 independent variables and 1 dependent variable is used. Data analysis was done using Quadratic regression. The statistical population of the study includes data from Eghtesade Novin, Parsian, Pasargad, Post Bank, Tejarat, Export Development Bank, Refah, Saman, Sepah, Sarmayeh, Sina, Karafarin, Bank of Industry and Mine, Melli, Mellat, Maskan and Keshavarzi banks during 2005-2013. The results showed that current deposits, investment deposits, saving deposits, long-term and short-term investment deposits have significantly positive impact on total bank incomes, but the other types of deposits have negative impact on bank income. In addition, the estimation accuracy for response surface methodology, in this research, is 95%.