Introduction: The overall objective of disaster epidemiology is to measure scientifically and describe the health impacts disasters and the factors contributing. The result of such surveys allow disaster epidemiologist to assess the needs of disaster affected people and plan for future disasters. The region of EMRO belongs to geography division of WHO, that is included 22 countries. The eastern outskirt is Pakistan and Afghanistan and western one is Tunisia and Morocco. Iran is occurred in near the east boundary. The aim of this study was the comparison occurred disasters in this region. Methods: For the collection of data has been used of the CRED-EMDAT international database. All of deaths, number of affected people and loss of cost was assessed by country in fourth recently years. Finally the important disaster was denoted base on the highest number of deaths.Results: The total deaths, affected people and economic loss were 536,130- 149,338,075 and 42,758,273 ($), respectively. About 698 disasters were happened in this period and the most of frequent were earthquake, flood, drought, storm and mass movement wet. Base on number of deaths, the drought of Sudan has the first rank (150,000 in Apr, 1983), the earthquake of Pakistan is the second (73,338 in Oct 2005) and the third is the Rodabar- Manjil earthquake of Iran (40,000 Juan 1990). The overall disasters of Iran are about 184 that included the 155,495 deaths, 44,057, 480 affected and the totally economic losses were 21,499,696 dollars.Conclusion: The results showed that the high frequent of important disaster in EMRO region. Most of EMRO countries is developing, then the occurring of major disasters can be destroyed the structures and lives. The appropriate investigations such as conducting the Regional Disaster Managements Committee can be useful.