PRODUCTION OF PHARMACEUTICAL ACTIVE INGREDIENTS VIA HAIRY ROOT INDUCTION OF BIRCH (BETULA PENDULA)

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JAFARI HAJATI R.; PAYAMNOOR V.; GHASEMI BEZDI K.; AHMADIAN CHASHMI N.

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Paper Information

Journal: Iranian Journal of Rangelands and Forests Plant Breeding and Genetic Research Year:2016 | Volume:24 | Issue:2 Page(s): 165-176

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Title

PRODUCTION OF PHARMACEUTICAL ACTIVE INGREDIENTS VIA HAIRY ROOT INDUCTION OF BIRCH (BETULA PENDULA)

Author(s)

JAFARI HAJATI R. | PAYAMNOOR V. | GHASEMI BEZDI K. | AHMADIAN CHASHMI N. | Issue Writer Certificate

Keywords

ANTIOXIDANTQ2

BETULA PENDULAQ1

BETULINQ1

BETULINIC ACIDQ2

HAIRY ROOTQ1

Abstract

Betula pendula Roth produces a range of biologically active terpenoids such as BETULIN and BETULINic acid. The compounds with cytotoxic effects which have been used for their medicinal properties. Agrobacterium-infected HAIRY ROOTs are characterized by high growth rate and genetic stability that can be provided noticeable amounts of the biological material. In this study, production of HAIRY ROOTs by B. pendula was investigated on different explants, media and A. rhizogenes strains. Growth rate of HAIRY ROOTs were studied during 20 days and the terpenoids content (betulin & BETULINic acid) were assayed by HPLC. HAIRY ROOT cultures were established 20 days after infection by infecting bark segments of B. pendula by Agrobactrium strains of C58C1and LB9402 in WPM medium. Growth of HAIRY ROOT by lines of C58C1 strain (D and E lines) and one line fromLB9402 strain (LB1) were significantly better than others. The most BETULIN content was observed in the HAIRY ROOTs, 8 days after culture, which was about 0.47 mg g-1 dry waight (DW). Furthermore, the most amount of ANTIOXIDANT activity (75%) was assessed on E line roots, 20 days after cultures. Although the highest content of BETULINic acid (0.6 mg g-1 DW) was obtained by LB1 lines but BETULIN content and ANTIOXIDANT activity were considerably less than other HAIRY ROOT lines. Results indicated that due to higher relative performance, E line of HAIRY ROOTs could be used for analysis of terpenoids and pharmaceutically important metabolites in future studies.

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APA: Copy

JAFARI HAJATI, R., PAYAMNOOR, V., GHASEMI BEZDI, K., & AHMADIAN CHASHMI, N.. (2016). PRODUCTION OF PHARMACEUTICAL ACTIVE INGREDIENTS VIA HAIRY ROOT INDUCTION OF BIRCH (BETULA PENDULA). IRANIAN JOURNAL OF RANGELANDS AND FORESTS PLANT BREEDING AND GENETIC RESEARCH, 24(2), 165-176. SID. https://sid.ir/paper/104180/en

Vancouver: Copy

JAFARI HAJATI R., PAYAMNOOR V., GHASEMI BEZDI K., AHMADIAN CHASHMI N.. PRODUCTION OF PHARMACEUTICAL ACTIVE INGREDIENTS VIA HAIRY ROOT INDUCTION OF BIRCH (BETULA PENDULA). IRANIAN JOURNAL OF RANGELANDS AND FORESTS PLANT BREEDING AND GENETIC RESEARCH[Internet]. 2016;24(2):165-176. Available from: https://sid.ir/paper/104180/en

IEEE: Copy

R. JAFARI HAJATI, V. PAYAMNOOR, K. GHASEMI BEZDI, and N. AHMADIAN CHASHMI, “PRODUCTION OF PHARMACEUTICAL ACTIVE INGREDIENTS VIA HAIRY ROOT INDUCTION OF BIRCH (BETULA PENDULA),” IRANIAN JOURNAL OF RANGELANDS AND FORESTS PLANT BREEDING AND GENETIC RESEARCH, vol. 24, no. 2, pp. 165–176, 2016, [Online]. Available: https://sid.ir/paper/104180/en

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