EFFECTS OF HYDRO-ALCOHOLIC EXTRACT OF ERIOBOTRYA JAPONICA LINDL. FLOWERS ON CDNF, SOD AND MDA LEVELS OF CEREBRAL CORTEX IN EXPERIMENTAL MODEL OF PARKINSON’S DISEASE IN RAT

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ASLANI J.; HAJIZADEH MOGHADDAM A.; FALLAH MOHAMMADI Z.; ISMAILI A.R.; MOHAMMADI R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF MEDICINAL AND AROMATIC PLANTS Year:2015 | Volume:31 | Issue:2 (70) Page(s): 332-341

Download Full-Text

Persian Verion

View:

879

Download:

Cites:

Information Journal Paper

Title

EFFECTS OF HYDRO-ALCOHOLIC EXTRACT OF ERIOBOTRYA JAPONICA LINDL. FLOWERS ON CDNF, SOD AND MDA LEVELS OF CEREBRAL CORTEX IN EXPERIMENTAL MODEL OF PARKINSON’S DISEASE IN RAT

Author(s)

Keywords

ERIOBOTRYA JAPONICA LINDL. FLOWERSQ2

CDNFQ2

SODQ2

MDAQ2

PARKINSONQ2

Abstract

The flowers of Eriobotrya japonica Lindl. have antioxidant and protective effects. The aim of this study was to investigate the effects of neuroprotection with hydro-alcoholic extract of Eriobotrya japonica flowers on CDNF, malondialdehyde and superoxide dismutase levels in the rat cerebral cortex in an experimental model of PARKINSON’s disease. In this study, animals were randomly divided into three groups of nine each (control, damaged and damaged treated with plant extract). At first, the second and third groups of rats received the solvent of extract (saline) and the extract (200 mg/kg body weight) intraperitoneally for twelve weeks and three days per week, respectively. For PARKINSON’s disease in rats, 6-OHDA was injected into the right ventricle of the brain after 12 weeks. After five daThe flowers of Eriobotrya japonica Lindl. have antioxidant and protective effects. The aim of this study was to investigate the effects of neuroprotection with hydro-alcoholic extract of Eriobotrya japonica flowers on CDNF, malondialdehyde and superoxide dismutase levels in the rat cerebral cortex in an experimental model of PARKINSON’s disease. In this study, animals were randomly divided into three groups of nine each (control, damaged and damaged treated with plant extract). At first, the second and third groups of rats received the solvent of extract (saline) and the extract (200 mg/kg body weight) intraperitoneally for twelve weeks and three days per week, respectively. For PARKINSON’s disease in rats, 6-OHDA was injected into the right ventricle of the brain after 12 weeks. After five days, rats were sacrificed and CDNF, SOD and MDA levels in their cortex were measured. Data were analyzed using ANOVA test. Our results showed that pre-treatment with the flower extract of Eriobotrya japonica, increased CDNF and SOD and decreased MDA levels of cerebral cortex. These effects may be caused by phenolic and flavonoid compounds of this plant with strong antioxidant properties. Therefore, it could be concluded that this plant extract has protective role against PARKINSON’s disease because of protecting neurons against oxidative damage of toxic 6-OHDA.ys, rats were sacrificed and CDNF, SOD and MDA levels in their cortex were measured. Data were analyzed using ANOVA test. Our results showed that pre-treatment with the flower extract of Eriobotrya japonica, increased CDNF and SOD and decreased MDA levels of cerebral cortex. These effects may be caused by phenolic and flavonoid compounds of this plant with strong antioxidant properties. Therefore, it could be concluded that this plant extract has protective role against PARKINSON’s disease because of protecting neurons against oxidative damage of toxic 6-OHDA.

Cites

No record.

References

No record.

Cite

APA: Copy

ASLANI, J., HAJIZADEH MOGHADDAM, A., FALLAH MOHAMMADI, Z., ISMAILI, A.R., & MOHAMMADI, R.. (2015). EFFECTS OF HYDRO-ALCOHOLIC EXTRACT OF ERIOBOTRYA JAPONICA LINDL. FLOWERS ON CDNF, SOD AND MDA LEVELS OF CEREBRAL CORTEX IN EXPERIMENTAL MODEL OF PARKINSON’S DISEASE IN RAT. IRANIAN JOURNAL OF MEDICINAL AND AROMATIC PLANTS, 31(2 (70)), 332-341. SID. https://sid.ir/paper/104678/en

Vancouver: Copy

ASLANI J., HAJIZADEH MOGHADDAM A., FALLAH MOHAMMADI Z., ISMAILI A.R., MOHAMMADI R.. EFFECTS OF HYDRO-ALCOHOLIC EXTRACT OF ERIOBOTRYA JAPONICA LINDL. FLOWERS ON CDNF, SOD AND MDA LEVELS OF CEREBRAL CORTEX IN EXPERIMENTAL MODEL OF PARKINSON’S DISEASE IN RAT. IRANIAN JOURNAL OF MEDICINAL AND AROMATIC PLANTS[Internet]. 2015;31(2 (70)):332-341. Available from: https://sid.ir/paper/104678/en

IEEE: Copy

J. ASLANI, A. HAJIZADEH MOGHADDAM, Z. FALLAH MOHAMMADI, A.R. ISMAILI, and R. MOHAMMADI, “EFFECTS OF HYDRO-ALCOHOLIC EXTRACT OF ERIOBOTRYA JAPONICA LINDL. FLOWERS ON CDNF, SOD AND MDA LEVELS OF CEREBRAL CORTEX IN EXPERIMENTAL MODEL OF PARKINSON’S DISEASE IN RAT,” IRANIAN JOURNAL OF MEDICINAL AND AROMATIC PLANTS, vol. 31, no. 2 (70), pp. 332–341, 2015, [Online]. Available: https://sid.ir/paper/104678/en

Related Journal Papers