ASSOCIATION BETWEEN ABNORMALITIES OF CHROMOSOME 8 AND PROGNOSIS IN BREAST CANCER

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BAHJATI F.; ATRI M.; NAJMABADI H.; MAHDIPOUR P.

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Journal: MODERN GENETICS JOURNAL (MGJ) Year:2008 | Volume:2 | Issue:4 Page(s): 57-64

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Title

ASSOCIATION BETWEEN ABNORMALITIES OF CHROMOSOME 8 AND PROGNOSIS IN BREAST CANCER

Author(s)

BAHJATI F. | ATRI M. | NAJMABADI H. | MAHDIPOUR P. | Issue Writer Certificate

Keywords

BREAST CANCERQ3

IRANIAN WOMENQ3

INTERPHASE FISHQ3

CLINICOPATHOLOGICAL PARAMETERSQ3

CHROMOSOME ANEUSOMY PROGNOSISQ3

Abstract

BREAST CANCER is amongst the leading causes of death in women worldwide and the most common cancer amongst IRANIAN WOMEN. Unfortunately, the current clinical and histological criteria can only help 60 percent of women with BREAST CANCER in diagnosis and long term treatment. Therefore, genetic markers both at single gene level and chromosomes can play an important role in improving the diagnosis and prognosis of BREAST CANCER patients. The aim of this retrospective study was to investigate the role of chromosome 8 copy number assessed by Interphase Fluorescence In Situ Hybridization (FISH), as the genetic prognostic parameter in 25 IRANIAN WOMEN, aged 35 to 64 years with sporadic primary invasive ductal breast carcinoma. Chromosome copy number was evaluated in relation to established CLINICOPATHOLOGICAL PARAMETERS, the immunohistochemical markers of ER, PR, P53, Cathepsin D, DNA Index by flow cytometry, age and the duration and status of survival in the patients. FISH, using centromeric probes for chromosome 8 was applied to interphase cell suspensions all prepared from the camoy fixed tumor cells and selected paraffin embedded tumor sections. More than 3000 cells for chromosome 8 were assessed. Aneosomy for chromosome 8 was present in all 25 patients to different levels. The total abnormality rate for chromosome 8 was 35 percent. This was similar to other reported cases. Increased mean number of cells with hypodiploidy for chromosome 8 was observed in patients under 51 years of age, lack of progestrone reseptor, raised level of cathepsin D, bigger tumor size, axilliay lymph node methastasis and being positive for P53 protein. All these clinical and immunohistochemical parameters are regarded as poor prognostic indicators in BREAST CANCER. In conclusion, chromosome 8 hypodiploidy alongside other clinical and pathological parameters may be considered as useful prognostic markers in invasive ductal carcinoma of breast in future.

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APA: Copy

BAHJATI, F., ATRI, M., NAJMABADI, H., & MAHDIPOUR, P.. (2008). ASSOCIATION BETWEEN ABNORMALITIES OF CHROMOSOME 8 AND PROGNOSIS IN BREAST CANCER. MODERN GENETICS JOURNAL (MGJ), 2(4), 57-64. SID. https://sid.ir/paper/116533/en

Vancouver: Copy

BAHJATI F., ATRI M., NAJMABADI H., MAHDIPOUR P.. ASSOCIATION BETWEEN ABNORMALITIES OF CHROMOSOME 8 AND PROGNOSIS IN BREAST CANCER. MODERN GENETICS JOURNAL (MGJ)[Internet]. 2008;2(4):57-64. Available from: https://sid.ir/paper/116533/en

IEEE: Copy

F. BAHJATI, M. ATRI, H. NAJMABADI, and P. MAHDIPOUR, “ASSOCIATION BETWEEN ABNORMALITIES OF CHROMOSOME 8 AND PROGNOSIS IN BREAST CANCER,” MODERN GENETICS JOURNAL (MGJ), vol. 2, no. 4, pp. 57–64, 2008, [Online]. Available: https://sid.ir/paper/116533/en

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