DETECTION OF K-RAS ONCOGEN MUTATION IN CODON 13 OF CRC PATIENTS IN EAST-NORTH OF IRAN

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LARY S.; GHAFFARZADEGAN K.; AFSHARNEZHAD S.; SARAF YAZDI M.; PAZOOKI N.; HOSEINKHANI S.

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Journal: MODERN GENETICS JOURNAL (MGJ) Year:2012 | Volume:6 | Issue:4 (27) Page(s): 43-47

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Title

DETECTION OF K-RAS ONCOGEN MUTATION IN CODON 13 OF CRC PATIENTS IN EAST-NORTH OF IRAN

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Keywords

COLORECTAL CANCERQ2

K-RASQ2

RFLP-PCRQ2

Abstract

introduction: COLORECTAL CANCER is one of the most common forms of cancer in the world. Among several genetic events which have been documented in colorectal tumour progression, K-RAS has high diagnostic value. Studies have shown that K-RAS mutations are found in 20-50% of all colon cancers mostly in codons 12 and 13, and less frequently in codon 61.The aim of the present study is to identify K-RAS gene mutations in codon 13 in CRC patients among the East-North of IRAN, and to assess whether they are linked to the clinicopathological parameters. Materials and Methods: Tumor samples were collected from a consecutive series of 54 patients undergone respective surgery for CRC.DNA was extracted from tumour and RFLP-PCR was applied for codon 13 mutation detection. Results: The results reveal that 18.51% of the patients (10/54) have the mutation in the K-RAS gene-codon 13. In the present study, K-RAS mutations were significantly associated with CRC stage (P<0.05). No significant correlations were found between the mutations and sex, grade and tumor location.Conclution: The research shows that mutations in K-RAS gene-codon 13 have a significant role in tumor type cell progression in CRC patients; therefore, screening for K-RAS mutations appears to have a high prognostic value for evaluating of the risk of the tumor progression.

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APA: Copy

LARY, S., GHAFFARZADEGAN, K., AFSHARNEZHAD, S., SARAF YAZDI, M., PAZOOKI, N., & HOSEINKHANI, S.. (2012). DETECTION OF K-RAS ONCOGEN MUTATION IN CODON 13 OF CRC PATIENTS IN EAST-NORTH OF IRAN. MODERN GENETICS JOURNAL (MGJ), 6(4 (27)), 43-47. SID. https://sid.ir/paper/116557/en

Vancouver: Copy

LARY S., GHAFFARZADEGAN K., AFSHARNEZHAD S., SARAF YAZDI M., PAZOOKI N., HOSEINKHANI S.. DETECTION OF K-RAS ONCOGEN MUTATION IN CODON 13 OF CRC PATIENTS IN EAST-NORTH OF IRAN. MODERN GENETICS JOURNAL (MGJ)[Internet]. 2012;6(4 (27)):43-47. Available from: https://sid.ir/paper/116557/en

IEEE: Copy

S. LARY, K. GHAFFARZADEGAN, S. AFSHARNEZHAD, M. SARAF YAZDI, N. PAZOOKI, and S. HOSEINKHANI, “DETECTION OF K-RAS ONCOGEN MUTATION IN CODON 13 OF CRC PATIENTS IN EAST-NORTH OF IRAN,” MODERN GENETICS JOURNAL (MGJ), vol. 6, no. 4 (27), pp. 43–47, 2012, [Online]. Available: https://sid.ir/paper/116557/en

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