EVALUATION OF TP53 CODON 72 POLYMORPHISM AND RESULTED PROTEIN IN BREAST CANCER PATIENTS IN YAZD CITY

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SHEIKHPOUR ROBAB; TAGHIPOUR ZAHIR SHOKOUH

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Journal: Iranian Journal of Breast Diseases Year:2014 | Volume:7 | Issue:3 Page(s): 20-29

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Title

EVALUATION OF TP53 CODON 72 POLYMORPHISM AND RESULTED PROTEIN IN BREAST CANCER PATIENTS IN YAZD CITY

Author(s)

SHEIKHPOUR ROBAB | TAGHIPOUR ZAHIR SHOKOUH | Issue Writer Certificate

Keywords

POLYMORPHISM CODON 72Q2

P53 GENEQ3

BREAST CANCERQ3

Abstract

Background: BREAST CANCER is the most common cancer in women. P53 is the most important tumor suppressor genes and genetic polymorphism of p53 is known as a risk factor for BREAST CANCER. P53 mutation has been seen in 20-40% of BREAST CANCER patients. DNA damage causes p53 phosphorylation and p53 accumulation in nucleus. Therefore the aim of this study is assess the evaluation of p53 Arg/Pro polymorphism at codon 72 and expression of p53 protein in BREAST CANCER women in Yazd city.Methods: In case-control study, 104 patients with BREAST CANCER and 104 matched controls in Yazd city were chosen. After DNA extraction, P53 codon 72 polymorphism was determined by ARMS-PCR technique and P53 overexpression was evaluated by immunohistochemistry method.Results: In BREAST CANCER patients group, the distribution of codon 72 polymorphism for Arg/Arg, Pro/Pro and Arg/Pro is 49.04, 21.15 and 29.81 percent respectively and in control group is 21.15, 26.92 and 51.93 percent respectively. The significant difference was seen between distribution of Arg/Arg and Arg/Pro genotype in BREAST CANCER patients and control group (P˂0.05). Also P53 negative was observed in 71.15% and p53 positive in 28.8% of BREAST CANCER patients. Therefore, significant difference was seen between p53 positive and negative (P<0.01).Conclusion: The results of this study showed that Arg/Arg genotype is a talented genetic factor for BREAST CANCER, while Arg/Pro genotype has protective role against BREAST CANCER.Also the tumor tissues of BREAST CANCER patients have shown different levels of p53 protein.

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APA: Copy

SHEIKHPOUR, ROBAB, & TAGHIPOUR ZAHIR, SHOKOUH. (2014). EVALUATION OF TP53 CODON 72 POLYMORPHISM AND RESULTED PROTEIN IN BREAST CANCER PATIENTS IN YAZD CITY. IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE, 7(3), 20-29. SID. https://sid.ir/paper/144603/en

Vancouver: Copy

SHEIKHPOUR ROBAB, TAGHIPOUR ZAHIR SHOKOUH. EVALUATION OF TP53 CODON 72 POLYMORPHISM AND RESULTED PROTEIN IN BREAST CANCER PATIENTS IN YAZD CITY. IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE[Internet]. 2014;7(3):20-29. Available from: https://sid.ir/paper/144603/en

IEEE: Copy

ROBAB SHEIKHPOUR, and SHOKOUH TAGHIPOUR ZAHIR, “EVALUATION OF TP53 CODON 72 POLYMORPHISM AND RESULTED PROTEIN IN BREAST CANCER PATIENTS IN YAZD CITY,” IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE, vol. 7, no. 3, pp. 20–29, 2014, [Online]. Available: https://sid.ir/paper/144603/en

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