The Effect of CoQ10 on Testicular Tissue in Rats Treating with Busulfan: Sperm Quality and Histological Changes

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Moloody Tappe Moones; SHAHROOZ RASOUL; RAZI MAZDAK; ZAREI LEILA; MOHAMMADI VAHID

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Journal: Iranian Journal of Veterinary Surgery Year:2018 | Volume:13 | Issue:1 (28) Page(s): 29-38

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Title

The Effect of CoQ10 on Testicular Tissue in Rats Treating with Busulfan: Sperm Quality and Histological Changes

Author(s)

Keywords

CoQ10Q1

BusulfanQ1

TestisQ1

RatsQ2

Abstract

Objective-Busulfan (Bus) is a chemotherapy drug that is widely used for cancer treatment. The protective effect of CoQ10 evaluated on Testis and sperm parameters after Busulfan treatment. Design-Experimental Study Animals-Thirty tow adult male Wistar Rats Procedures-In this experimental study 32 adult male Wistar Rats have randomly divided into four groups: Control group received normal saline (0. 1 mL, daily, intraperitoneally). Sham group received a single dose of Busulfan 10 mg/kg, IP. Positive control group received 0. 1 mL CoQ10 (10 mg/kg, daily, IP). The treatment group received Busulfan along with CoQ10 (10 mg/kg, daily, IP). All procedures were continued for 35 days. For histomorphometric analyses, the thickness of testicular capsule, the germinal epithelium height and the diameter of the seminiferous tubules were measured. Semen analysis was used for the assessment of sperm parameters.

Cites

Crocin Reduces Oxidative Stress Produced by Busulfan Administration on Fertility of Male Rats

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APA: Copy

Moloody Tappe, Moones, SHAHROOZ, RASOUL, RAZI, MAZDAK, ZAREI, LEILA, & MOHAMMADI, VAHID. (2018). The Effect of CoQ10 on Testicular Tissue in Rats Treating with Busulfan: Sperm Quality and Histological Changes. IRANIAN JOURNAL OF VETERINARY SURGERY (IJVS), 13(1 (28) ), 29-38. SID. https://sid.ir/paper/135711/en

Vancouver: Copy

Moloody Tappe Moones, SHAHROOZ RASOUL, RAZI MAZDAK, ZAREI LEILA, MOHAMMADI VAHID. The Effect of CoQ10 on Testicular Tissue in Rats Treating with Busulfan: Sperm Quality and Histological Changes. IRANIAN JOURNAL OF VETERINARY SURGERY (IJVS)[Internet]. 2018;13(1 (28) ):29-38. Available from: https://sid.ir/paper/135711/en

IEEE: Copy

Moones Moloody Tappe, RASOUL SHAHROOZ, MAZDAK RAZI, LEILA ZAREI, and VAHID MOHAMMADI, “The Effect of CoQ10 on Testicular Tissue in Rats Treating with Busulfan: Sperm Quality and Histological Changes,” IRANIAN JOURNAL OF VETERINARY SURGERY (IJVS), vol. 13, no. 1 (28) , pp. 29–38, 2018, [Online]. Available: https://sid.ir/paper/135711/en

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