Effects of Curcumin Nanoparticles on the Tissue Oxidative Stress Following Testicular Torsion and Detorsion in Rat Model

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Esmaeilsani Zaman; BARATI FARID; ALI MOHAMMADI RAHIM; SHAMS ESFANDABADI NASER; KARIMI IRAJ

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Journal: Iranian Journal of Veterinary Surgery Year:2019 | Volume:14 | Issue:2 (31) Page(s): 97-104

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Title

Effects of Curcumin Nanoparticles on the Tissue Oxidative Stress Following Testicular Torsion and Detorsion in Rat Model

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Keywords

Ischemia-reperfusionQ1

Curcumin nanoparticleQ1

Testicular torsionQ2

Abstract

Objective-The aim of the present study was to investigate the effects of Curcumin nanoparticles (CNP) on stress oxidative following experimental Ischemia-reperfusion injury in the rat testes. Design-Experimental Study Animals-Seventy-seven healthy male Wistar rats Procedures-The animals weighing approximately 250 g were randomly assigned to four experimental groups (n = 18): Ischemia: torsion group (created by 720° rotation of testis on both sides for 2 h). Ischemia/Reperfusion (I/R): torsion for 2 h followed distortion, CNP 10: received 10 mg/kg IP administration of CNP 30 min before surgery then remaining testes were twisted and untwisted, CNP 20: received 20 mg/kg IP administration of CNP 30 min before surgery then remaining testicles were twisted and untwisted. Unilateral orchiectomy of left or right testicles was performed on days 0 and 12 with immediately sampling. Some twisted then untwisted testicles were remained and sampled 60 days after surgery. An additional group was considered (n=5) to be sampled without any operation as control group. The samples of testicular tissue homogenates were taken on Days 0, 12 and 60, and their liquid extracts were collected and assayed for Superoxide dismutase (SOD), Malondialdehyde (MDA) and Glutathione peroxidase (GPX). The effect of treatment and day of sampling on the variables was analyzed using Two-Way ANOVA. Results-The results of the study showed an ameliorated balance of GPX, SOD and MDA following Testicular torsion in this study. The CNP treated animals (with both administered doses) showed significantly improved the balance of the enzymes compared to untreated animals (p<0. 0001). Conclusion and clinical relevance-In conclusion, IP administration of CNP may be helpful in minimizing oxidative stress related enzymes following testicular Ischemia-reperfusion in rat.

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APA: Copy

Esmaeilsani, Zaman, BARATI, FARID, ALI MOHAMMADI, RAHIM, SHAMS ESFANDABADI, NASER, & KARIMI, IRAJ. (2019). Effects of Curcumin Nanoparticles on the Tissue Oxidative Stress Following Testicular Torsion and Detorsion in Rat Model. IRANIAN JOURNAL OF VETERINARY SURGERY (IJVS), 14(2 (31) ), 97-104. SID. https://sid.ir/paper/135725/en

Vancouver: Copy

Esmaeilsani Zaman, BARATI FARID, ALI MOHAMMADI RAHIM, SHAMS ESFANDABADI NASER, KARIMI IRAJ. Effects of Curcumin Nanoparticles on the Tissue Oxidative Stress Following Testicular Torsion and Detorsion in Rat Model. IRANIAN JOURNAL OF VETERINARY SURGERY (IJVS)[Internet]. 2019;14(2 (31) ):97-104. Available from: https://sid.ir/paper/135725/en

IEEE: Copy

Zaman Esmaeilsani, FARID BARATI, RAHIM ALI MOHAMMADI, NASER SHAMS ESFANDABADI, and IRAJ KARIMI, “Effects of Curcumin Nanoparticles on the Tissue Oxidative Stress Following Testicular Torsion and Detorsion in Rat Model,” IRANIAN JOURNAL OF VETERINARY SURGERY (IJVS), vol. 14, no. 2 (31) , pp. 97–104, 2019, [Online]. Available: https://sid.ir/paper/135725/en

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