Effects of Local Transplantation of Autologous Bone Marrow Mesenchymal Stem Cells in Combination with Low Level Laser Therapy in Repair of Experimental Acute Spinal Cord Injury in Rats

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

IZADI SEYED SADRA; DEHGHAN MOHAMMAD MEHDI; SHARIFI DAVOOD; NASSIRI SEYED MEHDI; MARJANMEHR SEYED HOSSEIN; ZABIHI MARYAM; ASHRAFI HELAN JAVAD; Akbarein Hessam

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Veterinary Surgery Year:2017 | Volume:12 | Issue:1 (26) Page(s): 1-10

Download Full-Text

Persian Verion

View:

569

Download:

155

Cites:

Information Journal Paper

Title

Effects of Local Transplantation of Autologous Bone Marrow Mesenchymal Stem Cells in Combination with Low Level Laser Therapy in Repair of Experimental Acute Spinal Cord Injury in Rats

Author(s)

Keywords

Spinal cord injuryQ1

Mesenchymal stem cellsQ2

Low level laser therapyQ1

Abstract

Objective-The aim of this study was to demonstrate the efficacy of MSCs transplantation in combination with low level laser irradiation (LLLI) in repair of experimental acute Spinal cord injury. Design-Experimental study. Animals-28 adult male Wistar Rats. Procedures-A ballon-compression technique was used to produce an injury at the T8-T9 level of spinal cord applying Fogarty embolectomy catheter. In group-1, the autologous MSCs were transplanted to the spinal cord lesion and followed by treatment with low level laser irradiation during 15 consecutive days in group-2. The injured rats in third group were treated by LLLI alone. The functional recovery was assessed using the Basso-Beattie-Bresnahan (BBB) locomotion scoring within 5 weeks. Results-In these three treatment groups, the scores were significantly higher than control group. The differences between group-2 and two other treatment groups were statistically significant during all five weeks after treatment. There were no significant differences in BBB score between group-1(MSCs) and group-3(LLLI) at 3rd, 4th and 5th weeks of treatment. According to the histopathological findings, the best response was observed in group-2 (MSCs+LLLI) that repair of injured parts of dorsal funiculi and less cavitation were occurred by proliferation of Mesenchymal stem cells and their differentiation to glial cells especially oligodendrocytes resulting in axon regeneration and relatively spinal cord recovery. Conclusion and Clinical Relevance-The findings of present study demonstrated that concurrent use of LLLI and local transplantation of MSCs exhibited profound effects on axon regeneration and revealed remarkable functional improvement. These results suggested that MSCs characteristics could be influenced by low level laser irradiation, so this treatment might be as a useful procedure for neural regeneration, although further detailed investigations need to be carried out particularly in clinical cases.

Cites

No record.

References

Multipotent Stem Cell and Current Application

Cite

APA: Copy

IZADI, SEYED SADRA, DEHGHAN, MOHAMMAD MEHDI, SHARIFI, DAVOOD, NASSIRI, SEYED MEHDI, MARJANMEHR, SEYED HOSSEIN, ZABIHI, MARYAM, ASHRAFI HELAN, JAVAD, & Akbarein, Hessam. (2017). Effects of Local Transplantation of Autologous Bone Marrow Mesenchymal Stem Cells in Combination with Low Level Laser Therapy in Repair of Experimental Acute Spinal Cord Injury in Rats. IRANIAN JOURNAL OF VETERINARY SURGERY (IJVS), 12(1 (26) ), 1-10. SID. https://sid.ir/paper/135748/en

Vancouver: Copy

IZADI SEYED SADRA, DEHGHAN MOHAMMAD MEHDI, SHARIFI DAVOOD, NASSIRI SEYED MEHDI, MARJANMEHR SEYED HOSSEIN, ZABIHI MARYAM, ASHRAFI HELAN JAVAD, Akbarein Hessam. Effects of Local Transplantation of Autologous Bone Marrow Mesenchymal Stem Cells in Combination with Low Level Laser Therapy in Repair of Experimental Acute Spinal Cord Injury in Rats. IRANIAN JOURNAL OF VETERINARY SURGERY (IJVS)[Internet]. 2017;12(1 (26) ):1-10. Available from: https://sid.ir/paper/135748/en

IEEE: Copy

SEYED SADRA IZADI, MOHAMMAD MEHDI DEHGHAN, DAVOOD SHARIFI, SEYED MEHDI NASSIRI, SEYED HOSSEIN MARJANMEHR, MARYAM ZABIHI, JAVAD ASHRAFI HELAN, and Hessam Akbarein, “Effects of Local Transplantation of Autologous Bone Marrow Mesenchymal Stem Cells in Combination with Low Level Laser Therapy in Repair of Experimental Acute Spinal Cord Injury in Rats,” IRANIAN JOURNAL OF VETERINARY SURGERY (IJVS), vol. 12, no. 1 (26) , pp. 1–10, 2017, [Online]. Available: https://sid.ir/paper/135748/en

Related Journal Papers