HEALING EFFECT OF BONE MARROW DERIVED MESENCHYMAL STEM CELLS ON MOTOR SKILLS IN ACUTE SPINAL CORD INJURY, IN MICE

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GASHMARDI N.; MEHRABANI D.; HOSSEINI S.E.; EDALATMANESH M.A.; KHODABANDEH Z.

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Journal: Armaghane Danesh Year:2016 | Volume:21 | Issue:7 (114) Page(s): 669-681

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Title

HEALING EFFECT OF BONE MARROW DERIVED MESENCHYMAL STEM CELLS ON MOTOR SKILLS IN ACUTE SPINAL CORD INJURY, IN MICE

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Keywords

BONE MARROWQ2

MESENCHYMAL STEM CELLSQ2

LOCOMOTOR FUNCTIONQ1

SPINAL CORD INJURYQ1

TOYAMA MOUSE SCOREQ1

Abstract

Background & aim: Acute SPINAL CORD INJURY is a devastating damage that can cause a lot of motor and sensory deficits and reduce the quality of life and life expectancy of patients. Stem cell transplantation can be one of the promising therapeutic strategies. BONE MARROW is a rich source of stem cells that is enable to differentiate into various cell types. Due to the fact that thousands of people around the world suffer from spinal cord injuries there has been not found effective treatment for them until now. Therefore, this study aimed to investigate the differentiation and function in BONE MARROW stem cells transplanted into mice with SPINAL CORD INJURY has been done.Methods: BONE MARROW MESENCHYMAL STEM CELLS were Isolated from femurs and tibias of three mice and cultured. The mesenchymal properties of cells were investigated by morphology, differentiation into adipoblast and cell surface markers using RT-PCR. Thirty six Balb/c mice were randomly divided into 3 groups: the control, sham and experimental. Control group received no treatment. In sham group, mice were subjected to spinal cord compression in dorsal area and did not receive any treatment and In experimental group, one day after lesion, 3rd passage of BONE MARROW stem cells (2×105) were injected intravenously. Then assessment of LOCOMOTOR FUNCTION was done in open field by TOYAMA MOUSE SCORE (TMS) durig 5 week post-injury. The collected data was analyzed using ANOVA and Tukey tests.Results: TMS score in both experimental and sham groups was lower than the control group, while it significantly increased after 5th week in experimental group compared to the sham group (p<.001).Conclusion: The results of this study showed that bone mesenchymal stem cell transplantation in rats with acute SPINAL CORD INJURY can lead to improved motor function after injury.

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APA: Copy

GASHMARDI, N., MEHRABANI, D., HOSSEINI, S.E., EDALATMANESH, M.A., & KHODABANDEH, Z.. (2016). HEALING EFFECT OF BONE MARROW DERIVED MESENCHYMAL STEM CELLS ON MOTOR SKILLS IN ACUTE SPINAL CORD INJURY, IN MICE. ARMAGHAN DANESH, 21(7 (114)), 669-681. SID. https://sid.ir/paper/78118/en

Vancouver: Copy

GASHMARDI N., MEHRABANI D., HOSSEINI S.E., EDALATMANESH M.A., KHODABANDEH Z.. HEALING EFFECT OF BONE MARROW DERIVED MESENCHYMAL STEM CELLS ON MOTOR SKILLS IN ACUTE SPINAL CORD INJURY, IN MICE. ARMAGHAN DANESH[Internet]. 2016;21(7 (114)):669-681. Available from: https://sid.ir/paper/78118/en

IEEE: Copy

N. GASHMARDI, D. MEHRABANI, S.E. HOSSEINI, M.A. EDALATMANESH, and Z. KHODABANDEH, “HEALING EFFECT OF BONE MARROW DERIVED MESENCHYMAL STEM CELLS ON MOTOR SKILLS IN ACUTE SPINAL CORD INJURY, IN MICE,” ARMAGHAN DANESH, vol. 21, no. 7 (114), pp. 669–681, 2016, [Online]. Available: https://sid.ir/paper/78118/en

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